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首页> 外文期刊>Cell and Tissue Research >Development and organization of polarity-specific segregation of primary vestibular afferent fibers in mice
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Development and organization of polarity-specific segregation of primary vestibular afferent fibers in mice

机译：小鼠初级前庭传入纤维的极性特异性分离的发展与组织

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A striking feature of vestibular hair cells is the polarized arrangement of their stereocilia as the basis for their directional sensitivity. In mammals, each of the vestibular end organs is characterized by a distinct distribution of these polarized cells. We utilized the technique of post-fixation transganglionic neuronal tracing with fluorescent lipid soluble dyes in embryonic and postnatal mice to investigate whether these polarity characteristics correlate with the pattern of connections between the endorgans and their central targets; the vestibular nuclei and cerebellum. We found that the cerebellar and brainstem projections develop independently from each other and have a non-overlapping distribution of neurons and afferents from E11.5 on. In addition, we show that the vestibular fibers projecting to the cerebellum originate preferentially from the lateral half of the utricular macula and the medial half of the saccular macula. In contrast, the brainstem vestibular afferents originate primarily from the medial half of the utricular macula and the lateral half of the saccular macula. This indicates that the line of hair cell polarity reversal within the striola region segregates almost mutually exclusive central projections. A possible interpretation of this feature is that this macular organization provides an inhibitory side-loop through the cerebellum to produce synergistic tuning effects in the vestibular nuclei. The canal cristae project to the brainstem vestibular nuclei and cerebellum, but the projection to the vestibulocerebellum originates preferentially from the superior half of each of the cristae. The reason for this pattern is not clear, but it may compensate for unequal activation of crista hair cells or may be an evolutionary atavism reflecting a different polarity organization in ancestral vertebrate ears.
机译：前庭毛细胞的显着特征是其纤毛的极化排列，作为其方向敏感性的基础。在哺乳动物中，每个前庭末端器官的特征是这些极化细胞的明显分布。我们利用荧光脂溶性染料在胚胎和出生后小鼠中进行神经节后神经节示踪技术，以研究这些极性特征是否与内脏及其中央靶点之间的连接方式相关。前庭核和小脑。我们发现，小脑和脑干投影彼此独立发展，并且从E11.5开始具有神经元和传入神经的非重叠分布。此外，我们表明，突出到小脑的前庭纤维优先起源于球状黄斑的外侧一半和囊状黄斑的内侧一半。相反，脑干前庭传入细胞主要起源于眼球黄斑的内侧一半和囊状黄斑的外侧一半。这表明在纹状体区域内的毛细胞极性反转线几乎隔离了相互排斥的中央投影。该特征的可能解释是，该黄斑组织提供了通过小脑的抑制性侧环，以在前庭核中产生协同调节作用。运河cr突到脑干前庭核和小脑，但投射到前庭小脑的起源优先于每个cr突的上半部分。这种模式的原因尚不清楚，但它可以弥补cr头发的不平等激活，或者可能是进化的畸形，反映了祖先脊椎动物耳朵中不同极性的组织。

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