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首页> 外文期刊>Cell and Tissue Research >Proliferative cell types in embryonic lineages of the central complex of the grasshopper Schistocerca gregaria
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Proliferative cell types in embryonic lineages of the central complex of the grasshopper Schistocerca gregaria

机译：蝗虫血吸虫中央复合体胚胎谱系中的增殖细胞类型。

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The central complex of the grasshopper Schistocerca gregaria develops to completion during embryogenesis. A major cellular contribution to the central complex is from the w, x, y, z lineages of the pars intercerebralis, each of which comprises over 100 cells, making them by far the largest in the embryonic protocerebrum. Our focus has been to find a cellular mechanism that allows such a large number of cell progeny to be generated within a restricted period of time. Immunohistochemical visualization of the chromosomes of mitotically active cells has revealed an almost identical linear array of proliferative cells present simultaneously in each w, x, y, z lineage at 50% of embryogenesis. This array is maintained relatively unchanged until almost 70% of embryogenesis, after which mitotic activity declines and then ceases. The array is absent from smaller lineages of the protocerebrum not associated with the central complex. The proliferative cells are located apically to the zone of ganglion mother cells and amongst the progeny of the neuroblast. Comparisons of cell morphology, immunoreactivity (horseradish peroxidase, repo, Prospero), location in lineages and spindle orientation have allowed us to distinguish the proliferative cells in an array from neuroblasts, ganglion mother cells, neuronal progeny and glia. Our data are consistent with the proliferative cells being secondary (amplifying) progenitors and originating from a specific subtype of ganglion mother cell. We propose a model of the way that neuroblasts, ganglion mother cells and secondary progenitors together produce the large cell numbers found in central complex lineages.
机译：蚱SchSchistocerca gregaria的中央复合体在胚胎发生过程中发育到完全。中央脑复合体的主要细胞贡献来自脑间轴的w，x，y，z谱系，每个谱系包含100多个细胞，是迄今为止它们在胚胎前脑中最大的细胞。我们的重点是找到一种细胞机制，该机制允许在有限的时间内生成如此大量的细胞后代。有丝分裂活跃细胞的染色体的免疫组织化学可视化显示，在胚胎发生的50％时，每个w，x，y，z谱系同时存在着几乎相同的线性增殖细胞线性阵列。该阵列保持相对不变，直到几乎70％的胚胎发生，此后有丝分裂活性下降然后停止。与中央复合体无关的较小的前脑谱系不存在该阵列。增殖细胞位于神经节母细胞的顶端，并位于成神经细胞的后代中。细胞形态，免疫反应性（辣根过氧化物酶，回购，Prospero），谱系中的位置和纺锤体定向的比较使我们能够将阵列中的增殖细胞与成神经细胞，神经节母细胞，神经元后代和神经胶质细胞区分开。我们的数据与作为次要（扩增）祖细胞并起源于神经节母细胞特定亚型的增殖细胞一致。我们提出了神经母细胞，神经节母细胞和次级祖细胞一起产生中央复杂谱系中大量细胞的方式的模型。

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