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首页> 外文期刊>Cell and Tissue Research >Peptidergic paracrine and endocrine cells in the midgut of the fruit fly maggot
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Peptidergic paracrine and endocrine cells in the midgut of the fruit fly maggot

机译：果蝇fly中肠中的肽能旁分泌和内分泌细胞

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摘要

Endocrine cells in the larval midgut of Drosophila melanogaster are recognized by antisera to seven regulatory peptides: the allatostatins A, B, and C, short neuropeptide F, neuropeptide F, diuretic hormone 31, and the tachykinins. These are the same peptides that are produced by the endocrine cells of the adult midgut, except for short neuropeptide F, which is absent in adult midgut endocrine cells. The anterior larval midgut contains two types of endocrine cells. The first produces short neuropeptide F, which is also recognized by an antiserum to the receptor for the diuretic hormone leucokinin. The second type in the anterior midgut is recognized by an antiserum to diuretic hormone 31. The latter cell type is also found in the junction between the anterior and middle midgut; an additional type of endocrine cell in this region produces allatostatin B, a peptide also known as myoinhibitory peptide. Both types of endocrine cells in the junction between the anterior and middle midgut can express the homeodomain transcription factor labial. The copper cell region contains small cells that either produce allatostatin C or a combination of neuropeptide F, allatostatin B, and diuretic hormone 31. The latter cell type is also found in the region of the large flat cells. The posterior midgut possesses strongly immunoreactive allatostatin C endocrine cells immediately behind the iron cells. In the next part of the posterior midgut, two cell types have been found: one produces diuretic hormone 31, and a second is strongly immunoreactive to antiserum against the leucokinin receptor and weakly immunoreactive to antisera against allatostatins B and C and short neuropeptide F. The last part of the posterior midgut again has two types of endocrine cells: those that produce allatostatin A, and those that produce tachykinins. Many of the latter cells are also weakly immunoreactive to the antiserum against diuretic hormone 31. As in the adult, the insulin-like peptide 3 gene appears to be expressed by midgut muscles, but not by midgut endocrine cells.
机译：果蝇果蝇幼虫中肠中的内分泌细胞可被抗血清识别到七个调节肽：尿囊抑素A，B和C，短神经肽F，神经肽F，利尿激素31和速激肽。这些与成年中肠内分泌细胞产生的肽相同，除了短的神经肽F（成年中肠内分泌细胞中不存在）。前幼虫中肠含有两种类型的内分泌细胞。第一种产生短的神经肽F，它也被利尿激素白细胞分裂素受体的抗血清识别。利尿激素31的抗血清可以识别前肠的第二种类型。后者的细胞类型也见于中肠的前部和中间。在该区域中，另一种类型的内分泌细胞可产生阿托他汀B，该肽也称为肌抑制肽。前中肠和中肠之间的交界处的两种类型的内分泌细胞均可表达同源结构域转录因子唇。铜细胞区域包含小细胞，这些小细胞会产生阿托伐他汀C或神经肽F，阿托伐他汀B和利尿激素31的组合。后者的类型也见于大的扁平细胞区域。中肠后部在铁细胞后立即具有强烈的免疫反应性阿托伐他汀C内分泌细胞。在后中肠的下一部分，发现了两种细胞类型：一种产生利尿激素31，另一种对抗白细胞分裂素受体的抗血清具有强免疫反应性，对抗阿托伐他汀B和C以及短神经肽F的抗血清具有弱免疫反应性。后肠的最后一部分再次具有两种类型的内分泌细胞：产生altostatin A的细胞和产生速激肽的细胞。后者的许多细胞对利尿激素31的抗血清也具有弱免疫反应性。与成人一样，胰岛素样肽3基因似乎是由中肠肌肉表达的，而不是由中肠内分泌细胞表达的。

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