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首页> 外文期刊>Cell and Tissue Research >Mutual regulation of the Drosophila disconnected (disco) and Distal-less (Dll) genes contributes to proximal-distal patterning of antenna and leg
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Mutual regulation of the Drosophila disconnected (disco) and Distal-less (Dll) genes contributes to proximal-distal patterning of antenna and leg

机译：果蝇断链（disco）和无远端（Dll）基因的相互调节有助于触角和腿的近端-远端模式

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The Drosophila disconnected (disco) gene encodes a C2H2-type zinc finger transcription factor required for the development of the central and peripheral nervous systems. We report that disco participates in a positive feedback loop with the Dll gene, a master regulator of ventral appendage development. Dll function is not only required for proper disco expression in antenna and leg discs, but is also sufficient for ectopic expression of disco in the developing retina and wing imaginal discs. Conversely, disco gene function is required for the maintenance of Dll expression. We show that Dll phenotypes are partially rescued by the up-regulation of disco expression in the Dll domain. Reduction in disco gene function disrupts antenna and leg development, and the phenotypes closely resemble that produced by Dll alleles. These observations demonstrate that disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression.
机译：果蝇断链（disco）基因编码中枢和周围神经系统发育所需的C 2 H 2 型锌指转录因子。我们报告说，迪斯科舞会参与Dll基因的正反馈回路，Dll基因是腹侧附件发育的主要调节器。 Dll功能不仅是在天线和腿部椎间盘中正确表达迪斯科所必需的，而且对于发育中的视网膜和翼状假想椎间盘中异位表达迪斯科也足够了。相反，迪斯科基因功能是维持Dll表达所必需的。我们显示，Dll表型是通过Dll域中迪斯科表达的上调部分挽救的。迪斯科基因功能的降低会破坏触角和腿的发育，其表型与Dll等位基因产生的表型极为相似。这些观察结果表明，迪斯科舞会在依赖于天线和腿的Dll依赖模式中起着基本作用，也许是Dll基因表达的调节剂。

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