Retinal stem cells: promising candidates for retina transplantation

Meta W. Djojosubroto; Yvan Arsenijevic

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Retinal stem cells: promising candidates for retina transplantation

机译：视网膜干细胞：视网膜移植的有希望的候选人

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Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor degeneration, one of the major causes of blindness. In this review, we focus on the biology of retinal stem cells (RSCs) and progenitor cells (RPCs) isolated from fetal, postnatal, and adult animals, with emphasis on those from rodents and humans. We discuss the origin of RSCs/RPCs, the markers expressed by these cells and the conditions for the isolation, culture, and differentiation of these cells in vitro or in vivo by induction with exogenous stimulation.

机译：干细胞移植被广泛认为是光感受器变性的一种有前途的治疗方法，所述光感受器变性是失明的主要原因之一。在这篇综述中，我们重点研究从胎儿，出生后和成年动物中分离的视网膜干细胞（RSC）和祖细胞（RPC）的生物学，重点是啮齿动物和人类的视网膜干细胞。我们讨论了RSCs / RPCs的起源，这些细胞表达的标志物以及通过外源刺激诱导在体外或体内分离，培养和分化这些细胞的条件。

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《Cell and Tissue Research》 |2008年第1期|347-357|共11页
作者
Meta W. Djojosubroto; Yvan Arsenijevic;
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作者单位

Unit of Gene Therapy ampamp Stem Cell Biology Jules-Gonin Eye Hospital Ophthalmology Department University of Lausanne 15 Avenue de France 1004 Lausanne Switzerland;

Unit of Gene Therapy ampamp Stem Cell Biology Jules-Gonin Eye Hospital Ophthalmology Department University of Lausanne 15 Avenue de France 1004 Lausanne Switzerland;

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正文语种 eng
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关键词
Retina; Stem cells; Progenitor; Differentiation; Transplantation; Radial glia;

机译：视网膜;干细胞;祖细胞;分化;移植;Radi神经胶质;

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专利

1. Retinal stem cells: promising candidates for retina transplantation. [J] . Djojosubroto MW, Arsenijevic Y Cell and Tissue Research . 2008,第1期

机译：视网膜干细胞：视网膜移植的有希望的候选人。
2. 3D retina organoids produced from CRX-GFP human embryonic stem cells (hESCs) processed into retinal sheets and transplanted into immunodeficient retinal degenerate (RD) rats [J] . Seiler Magdalene J., McLelland Bryce T., Collin Joseph, Investigative ophthalmology & visual science . 2018,第9期

机译：3D视网膜器有器材由Crx-GFP人胚胎干细胞（HESC）加工成视网膜板并移植到免疫缺陷降解（RD）大鼠中
3. 3D retina organoids produced from CRX-GFP human embryonic stem cells (hESCs) processed into retinal sheets and transplanted into immunodeficient retinal degenerate (RD) rats [J] . Seiler Magdalene J., McLelland Bryce T., Collin Joseph, Investigative ophthalmology & visual science . 2018,第9期

机译：3D视网膜器有器材由Crx-GFP人胚胎干细胞（HESC）加工成视网膜板并移植到免疫缺陷降解（RD）大鼠中
4. In vivo visualizing the dynamics of bone marrow stem cells in mouse retina and choroidal-retinal circulation [C] . Heuy-Ching H. Wang, Harry Zwick, Peter R. Edsall, Ophthalmic Technologies XVII; Progress in Biomedical Optics and Imaging; vol.8 no.3; Proceedings of SPIE-The International Society for Optical Engineering; vol.6426 . 2007

机译：体内可视化小鼠视网膜和脉络膜-视网膜循环中骨髓干细胞的动力学
5. In-situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation in Rodent Retina [D] . Park, Jeayoung. 2019

机译：原位交联水凝胶作为啮齿动物视网膜视网膜祖细胞移植的载体
6. Glutamate Stimulation of Retinal Ganglion Cells in Normal and S334ter-4 Rat Retinas: A Candidate for a Neurotransmitter-Based Retinal Prosthesis [O] . Paul G. Finlayson, Raymond Iezzi -1

机译：谷氨酸刺激正常和S334ter-4大鼠视网膜中的视网膜神经节细胞：基于神经递质的视网膜假体的候选人。
7. Retinal stem cells: promising candidates for retina transplantation [O] . Meta W. Djojosubroto, Yvan Arsenijevic 2007

机译：视网膜干细胞：视网膜移植的有希望的候选者
8. Retinal Cell and Photoreceptor Transplantation Between Adult New Zealand RedRabbit Retinas [R] . Schusschereba, S. T., Silverman, M. S. 1992

机译：成人新西兰RedRabbit视网膜之间的视网膜细胞和光感受器移植

Retinal stem cells: promising candidates for retina transplantation

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