Neurogenesis in the adult hippocampus

Dan Ehninger; Gerd Kempermann

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Neurogenesis in the adult hippocampus

机译：成年海马神经发生

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摘要

New neurons continue to be generated in two privileged areas of the adult brain: the dentate gyrus of the hippocampal formation and the olfactory bulb. Adult neurogenesis has been found in all mammals studied to date, including humans. The process of adult neurogenesis encompasses the proliferation of resident neural stem and progenitor cells and their subsequent differentiation, migration, and functional integration into the pre-existing circuitry. This article summarizes recent findings regarding the developmental steps involved in adult hippocampal neurogenesis and the possible functional roles that new hippocampal neurons might play.

机译：在成人大脑的两个特权区域中继续产生新的神经元：海马结构的齿状回和嗅球。迄今为止，在包括人类在内的所有哺乳动物中都发现了成年神经发生。成年神经发生的过程包括常驻神经干细胞和祖细胞的增殖及其随后的分化，迁移和功能整合到先前存在的回路中。本文总结了有关成人海马神经发生的发育步骤以及新海马神经元可能发挥的功能作用的最新发现。

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《Cell and Tissue Research》 |2008年第1期|243-250|共8页
作者
Dan Ehninger; Gerd Kempermann;
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作者单位

Departments of Neurobiology Psychology and Psychiatry and the Brain Research Institute University of California Los Angeles 695 Charles Young Drive South Los Angeles CA 90095–1761 USA;

Center for Regenerative Therapies Dresden Am Tatzberg 47–49 01307 Dresden Germany;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Neural stem cells; Precursor cells; Adult neurogenesis; Hippocampus; Learning and memory;

机译：神经干细胞前体细胞成人神经发生海马学习记忆;

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1. Hormones and the regulation of adult neurogenesis in the hippocampus and beyond: Where are we now? Introduction to the special issue on hormonal regulation of adult neurogenesis: Implications for disease [J] . Galea Liisa A. M., Duarte-Guterman Paula Frontiers in neuroendocrinology . 2016,第Null期

机译：激素和海马及其他地方的成人神经发生的调控：我们现在在哪里？关于成人神经发生激素调节的特殊问题简介：对疾病的影响
2. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. [J] . Lee J, Duan W, Mattson MP Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2002,第6期

机译：有证据表明，脑源性神经营养因子是基础神经发生所必需的，并且在一定程度上介导了成年小鼠海马中通过饮食限制来促进神经发生。
3. Analysis of neural progenitors from embryogenesis to juvenile adult in Xenopus laevis reveals biphasic neurogenesis and continuous lengthening of the cell cycle Analysis of neural progenitors from embryogenesis to juvenile adult in Xenopus laevis reveals biphasic neurogenesis and continuous lengthening of the cell cycle Analysis of neural progenitors from embryogenesis to juvenile adult in Xenopus laevis reveals biphasic neurogenesis and continuous lengthening of the cell cycle [J] . Rapha?l Thuret, Hélène Auger, Nancy Papalopulu Biology Open . 2015,第12期

机译：非洲爪蟾从胚胎发生到成年成年的神经祖细胞的分析揭示了双相神经发生和细胞周期的持续延长分析非洲爪蟾从胚胎生成到成年成年的神经祖细胞的分析显示了双相神经发生和细胞周期的持续延长了从胚胎发生的神经祖细胞的分析爪蟾幼体的成年揭示了双相神经发生和细胞周期的持续延长
4. 5.6: Presentation session: Neuroscience informatics: “Genetic analysis of BDNF expression cliques and adult neurogenesis in the hippocampus” [C] . Mulligan Megan K. Proceedings of the 2010 Biomedical Sciences and Engineering Conference . 2010

机译：5.6：演讲环节：神经科学信息学：“ BDNF表达集团的基因分析和海马的成年神经发生”
5. The dentate gyrus of the hippocampus: roles of transforming growth factor beta1 (TGFbeta1) and adult neurogenesis in the expression of spatial memory. [D] . Martinez Canabal, Alonso. 2013

机译：海马齿状回：转化生长因子β1（TGFbeta1）和成人神经发生在空间记忆表达中的作用。
6. AAV ablates neurogenesis in the adult murine hippocampus [O] . Stephen Johnston, Sarah L Parylak, Stacy Kim, 2021

机译：AAV在成人鼠海马中消融神经发生
7. Transcriptomic Analysis of the Neurogenesis Signature suggests Continued but Minimal Neurogenesis in the Adult Human Hippocampus [O] . Ashutosh Kumar, Vikas Pareek, Muneeb A. Faiq, 2019

机译：神经发生签名的转录组分析表明成人人类海马中持续但神经发生最小

Neurogenesis in the adult hippocampus

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