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首页> 外文期刊>Cell and Tissue Research >Effect of a toxicant on phagocytosis pathways in the freshwater snail Lymnaea stagnalis
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Effect of a toxicant on phagocytosis pathways in the freshwater snail Lymnaea stagnalis

机译：有毒物质对淡水田螺天牛吞噬途径的影响

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摘要

The disturbance of plasma membrane carbohydrates and of lipopolysaccharide (LPS) ligands in relation to cytoskeletal transformations of haemocytes has been investigated after chronic exposure of pond snails (Lymnaea stagnalis) to the peroxidizing toxicant fomesafen. Neither of the two lectins used (concanavalin A and wheat germ agglutinin) showed any binding modification after incubation of the snails in the presence of the toxicant. However, after exposure of the snails to fomesafen, a clear and persistent reduction in LPS labelling of haemocytes occurred. The actin cytoskeleton of the same cells also appeared to be sensitive to the toxicant. The reduction in LPS-binding sites was related to actin staining, leading to the hypothesis that LPS ligands and actin could be similarly modulated by the toxicant. Damaged cells showed non-adherent membrane portions with reduced filopodial extrusions, exhibiting a smooth surface free of microvilli. These changes could lower the spreading and adhesion of the cells and could therefore account for the loss in their phagocytic capabilities.
机译：在将池塘蜗牛（长吻蛙）长期暴露于过氧化有毒富美沙芬之后，已经研究了与血细胞的细胞骨架转化有关的质膜碳水化合物和脂多糖（LPS）配体的干扰。在有毒物质存在下孵育蜗牛后，使用的两种凝集素（伴刀豆球蛋白A和小麦胚芽凝集素）均未显示任何结合修饰。但是，在将蜗牛暴露于芬莫美之后，血细胞的LPS标记明显且持续减少。同一细胞的肌动蛋白细胞骨架也似乎对毒物敏感。 LPS结合位点的减少与肌动蛋白染色有关，从而得出这样的假设，即LPS配体和肌动蛋白可以被毒物类似地调节。受损的细胞显示出非粘附的膜部分，减少了丝虫的挤压，表现出没有微绒毛的光滑表面。这些改变可能降低细胞的扩散和粘附，因此可以解释吞噬能力的丧失。

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