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首页> 外文期刊>Cell and Tissue Research >Regenerating cochlear hair cells: quo vadis stem cell
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Regenerating cochlear hair cells: quo vadis stem cell

机译：再生耳蜗毛细胞：vadis干细胞

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摘要

Many elderly people worldwide lose the neurosensory part of their ear and turn deaf. Cochlear implants to restore some hearing after neurosensory hearing loss are, at present, the only therapy for these people. In contrast to this therapy, replacement of hair cells via stem cell therapies holds the promise for a cure. We review here current insights into embryonic, adult, and inducible stem cells that might provide cells for seeding the cochlea with the hope of new hair cell formation. We propose a two-step approach using a first set of transcription factors to enhance the generation of inducible pluripotent stem (iPS) cells and a second set of factors to initiate the differentiation of hair cells. Recent evidence regarding ear development and stem cell research strongly suggest that microRNAs will be an important new regulatory factor in both iPS cell formation and differentiation to reprogram cells into hair cells. In addition, we highlight currently insurmountable obstacles to the successful transformation of stem cells into hair cell precursors and their injection into the cochlear canal to replace lost hair cells.
机译：世界各地的许多老年人失去了耳朵的神经感觉部分，并充耳不闻。目前，对于这些人而言，耳蜗植入物是在神经感觉性听力丧失后恢复部分听力的唯一疗法。与这种疗法相反，通过干细胞疗法替代毛细胞拥有治愈的希望。我们在这里回顾当前对胚胎干细胞，成年干细胞和可诱导干细胞的见解，这些干细胞可能会为植入耳蜗的细胞提供希望，以期形成新的毛细胞。我们提出了一种分两步的方法，即使用第一组转录因子来增强诱导型多能干（iPS）细胞的产生，并使用第二组因子来启动毛发细胞的分化。有关耳朵发育和干细胞研究的最新证据强烈表明，microRNA将成为iPS细胞形成和分化以重编程细胞为毛细胞的重要新调控因子。此外，我们强调了目前无法克服的障碍，这些障碍是干细胞成功转化为毛细胞前体以及将其注射到耳蜗中以替代丢失的毛细胞的障碍。

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  • 来源
    《Cell and Tissue Research》 |2008年第3期|373-379|共7页
  • 作者

    Kirk Beisel; Laura Hansen; Garrett Soukup; Bernd Fritzsch;

  • 作者单位

    Department of Biomedical Sciences Creighton University 2500 California Plaza Omaha NE 68178 USA;

    Department of Biomedical Sciences Creighton University 2500 California Plaza Omaha NE 68178 USA;

    Department of Biomedical Sciences Creighton University 2500 California Plaza Omaha NE 68178 USA;

    Department of Biology Iowa Entrepreneural Endowed Professor 143 Biology Building Iowa City IA 52242 USA;

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  • 正文语种 eng
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  • 关键词

    Hair cell loss; Stem cell therapy; iPS cells; miRNA; Transcription factors;

    机译：毛细胞丢失;干细胞治疗;iPS细胞;miRNA;转录因子;

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