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首页> 外文期刊>Cell and Tissue Research >A peripheral pacemaker drives the circadian rhythm of synaptic boutons in Drosophila independently of synaptic activity
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A peripheral pacemaker drives the circadian rhythm of synaptic boutons in Drosophila independently of synaptic activity

机译：外围起搏器独立于突触活动而驱动果蝇中突触钮扣的昼夜节律

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摘要

Circadian rhythms in the morphology of neurons have been demonstrated in the fly Drosophila melanogaster. One such rhythm is characterized by changes in the size of synaptic boutons of an identified flight motor neuron, with larger boutons during the day compared with those at night. A more detailed temporal resolution of this rhythm shows here that boutons grow at a time of increased locomotor activity during the morning but become gradually smaller during the day and second period of increased locomotor activity in the evening. We have experimentally manipulated the synaptic activity of the fly during short periods of the day to investigate whether changes in bouton size might be a consequence of the different levels of synaptic activity associated with the locomotion rhythm of the fly. In the late night and early morning, when the flies normally have an intense period of locomotion, the boutons grow independently of whether the flies are active or completely paralyzed. Bouton size is not affected by sleep-deprivation during the early night. The cycle in bouton size persists for 2 days even in decapitated flies, which do not move, reinforcing the notion that it is largely independent of synaptic activity, and showing that a pacemaker other than the main biological clock can drive it.
机译：在果蝇果蝇中已经证明了神经元形态的昼夜节律。一种这样的节律的特征在于，识别出的飞行运动神经元的突触钮扣的大小变化，白天与夜晚相比，白天的钮扣更大。这种节律的更详细的时间分辨率在这里显示，在早晨运动能力增强的时候，钮扣会增长，而在白天和晚上，运动能力增强的第二个时期会逐渐变小。我们已经在一天的短时间内对苍蝇的突触活动进行了实验性操作，以调查胸腺大小的变化是否可能是与苍蝇的运动节奏相关的不同水平的突触活动的结果。在深夜和清晨，果蝇通常会经历剧烈的运动，而果蝇无论活跃还是完全瘫痪，其grow突都会独立生长。 Bouton的大小不受深夜睡眠不足的影响。即使在断头的苍蝇中，其钮扣大小的周期也可持续2天，这些蝇不会移动，这进一步增强了这种观念，即其很大程度上独立于突触活动，并表明起搏器不是主要的生物钟就能驱动它。

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