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首页> 外文期刊>Cell and Tissue Research >Bone marrow as a source of stem cells and germ cells? Perspectives for transplantation
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Bone marrow as a source of stem cells and germ cells? Perspectives for transplantation

机译：骨髓是干细胞和生殖细胞的来源吗？移植前景

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Recent publications have suggested the existence of germ stem cells in the mouse at postnatal stages. The mechanism of de novo oocyte formation is proposed to involve a contribution from the bone marrow to the germ cell pool, via the bloodstream. Critical examination of the data underpinning these contentious claims is under way from a reproductive biology perspective but little has been said about the nature of this elusive bone marrow population with germ cell potential. Furthermore, whereas the prospect of marrow-derived germ cells may appear propitious for fertility applications, its wider impact on transplantation medicine remains to be considered. This paper examines the evidence leading to the current debate and considers the implications of such findings for the field of bone marrow transplantation.
机译：最近的出版物建议在小鼠出生后阶段存在生殖干细胞。提出从头卵母细胞形成的机制涉及通过血液从骨髓到生殖细胞库的贡献。从生殖生物学的角度出发，正在对构成这些争论主张的数据进行严格的检查，但对于这种具有生殖细胞潜力的难以捉摸的骨髓人群的性质却鲜有报道。此外，尽管源自骨髓的生殖细胞的前景似乎有利于生育应用，但其对移植医学的更广泛影响仍有待考虑。本文研究了导致当前争论的证据，并考虑了这些发现对骨髓移植领域的影响。

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