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首页> 外文期刊>Cell and Tissue Research >Distinct roles of lymphotoxin-β signaling and the homeodomain transcription factor Nkx2.3 in the ontogeny of endothelial compartments in spleen
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Distinct roles of lymphotoxin-β signaling and the homeodomain transcription factor Nkx2.3 in the ontogeny of endothelial compartments in spleen

机译：淋巴毒素-β信号转导和同源域转录因子Nkx2.3在脾脏内皮区室发育中的不同作用

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摘要

The formation of peripheral lymphoid tissues is indispensable for the efficient recognition and elimination of external antigens by lymphoid and accessory cells of the adaptive immune system. The spleen is structurally arranged around various vascular beds with distinct endothelial phenotypes. Using immunohistochemistry, we investigated the postnatal developmental characteristics of the marginal sinus and its relationship with various red-pulp sinus subsets. We also determined the importance of the lymphotoxin β receptor (LTβR) and the role of the Nkx2.3 transcription factor for the formation of the splenic vasculature. Both the administration of soluble LTβR-Ig fusion protein to neonates and the deletion of LTβR or downstream signaling components (RelB and p52) of the NF-κB family inhibited the phenotypic maturation of marginal sinus but had no effect on the vascular compartmentalization of the red pulp. The integrity of the marginal sinus and the proper vascular segregation of the red pulp appeared to be controlled by Nkx2.3, as Nkx2.3-deficient mice exhibited an abnormal distribution of IBL-7/1hi/IBL-9/2? sinuses and a lack of IBL-7/1lo/IBL-9/2+ vessels. Our data suggest that phenotypic heterogeneity among different vascular elements within distinct anatomical regions of the spleen differentially depends on developmental factors such as lymphotoxin signaling or Nkx2.3, whereas the marginal sinus is controlled by both pathways.
机译：外周淋巴组织的形成对于适应性免疫系统的淋巴和辅助细胞有效识别和消除外部抗原是必不可少的。脾在结构上围绕具有不同内皮表型的各种血管床排列。使用免疫组织化学，我们研究了边缘窦的产后发育特征及其与各种红浆窦亚群的关系。我们还确定了淋巴毒素β受体（LTβR）的重要性以及Nkx2.3转录因子在脾血管系统形成中的作用。对新生儿施用可溶性LTβR-Ig融合蛋白，以及删除NF-κB家族的LTβR或下游信号转导成分（RelB和p52），都抑制了边缘窦的表型成熟，但对红色的血管分隔没有影响。纸浆。 Nkx2.3控制着边缘窦的完整性和红髓的适当血管分离，因为Nkx2.3缺陷的小鼠表现出IBL-7 / 1hi / IBL-9 /的异常分布2？鼻窦和缺乏IBL-7 / 1lo / IBL-9 / 2 + 血管。我们的数据表明，脾脏不同解剖区域内不同血管成分之间的表型异质性差异取决于发育因素，例如淋巴毒素信号或Nkx2.3，而边缘窦受两种途径控制。

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  • 来源
    《Cell and Tissue Research》 |2007年第3期|473-486|共14页
  • 作者

    Péter Balogh; Mercedesz Balázs; Tamás Cz?mp?ly; Debra S. Weih; Hans-Henning Arnold; Falk Weih;

  • 作者单位

    Department of Immunology and Biotechnology Faculty of Medicine University of Pécs Szigeti út 12. H-7624 Pécs Hungary;

    Department of Immunology and Biotechnology Faculty of Medicine University of Pécs Szigeti út 12. H-7624 Pécs Hungary;

    Department of Immunology and Biotechnology Faculty of Medicine University of Pécs Szigeti út 12. H-7624 Pécs Hungary;

    Fritz Lipmann Institute Research Group Immunology Leibniz Institute for Age Research Jena Germany;

    Department of Cell and Molecular Biology Institute of Biochemistry ampamp Biotechnology Technical University of Braunschweig Braunschweig Germany;

    Fritz Lipmann Institute Research Group Immunology Leibniz Institute for Age Research Jena Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Spleen; Endothelium; Lymphotoxin/LT; RelB/NF-κB; Nkx2.3; Mouse (C57Bl/6; C.B-17/Icr scid/scid);

    机译：脾;内皮;淋巴毒素/LT;RelB/NF-κB;Nkx2.3;小鼠（C57Bl / 6;C.B-17 / Icr scid / scid）;

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