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首页> 外文期刊>Cell and Tissue Research >Distribution of vesicular glutamate transporter 1 (VGLUT1) in the mouse esophagus
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Distribution of vesicular glutamate transporter 1 (VGLUT1) in the mouse esophagus

机译：小鼠食道中囊泡谷氨酸转运蛋白1（VGLUT1）的分布

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In rat and mouse esophagus, vesicular glutamate transporter 2 (VGLUT2) has been demonstrated to identify vagal intraganglionic laminar endings (IGLEs); this has recently also been shown for VGLUT1 in rat esophagus. In this study, we have investigated the distribution of VGLUT1 in the mouse esophagus and compared these results with the recently published data from the rat esophagus. Unexpectedly, we have discovered that VGLUT1 mostly fails to identify IGLEs in the mouse esophagus. This is surprising, since the distribution of VGLUT2 shows comparable results in both species. Confocal imaging has revealed substantial colocalization of VGLUT1 immunoreactivity (-ir) with cholinergic and nitrergic/peptidergic markers within the myenteric neuropil and in both cholinergic and nitrergic myenteric neuronal cell bodies. VGLUT1 and cholinergic markers have also been colocalized in fibers of the muscularis mucosae, whereas VGLUT1 and nitrergic markers have never been colocalized in fibers of the muscularis mucosae, although this does occur in fibers of the muscularis running to motor endplates. Thus, VGLUT1 is contained in the nitrergic innervation of mouse esophageal motor endplates, another difference from the rat esophagus. VGLUT1-ir is therefore present in extrinsic and intrinsic innervation of the mouse esophagus, but the significant differences from the rat indicate species variations concerning the distribution of VGLUTs in the peripheral nervous system.
机译：在大鼠和小鼠的食道中，已证明囊状谷氨酸转运蛋白2（VGLUT2）可以识别迷走神经节内层状末端（IGLE）。最近在大鼠食道中的VGLUT1也显示出这种情况。在这项研究中，我们研究了VGLUT1在小鼠食道中的分布，并将这些结果与大鼠食道最近发表的数据进行了比较。出乎意料的是，我们发现VGLUT1主要无法识别小鼠食道中的IGLE。这是令人惊讶的，因为VGLUT2的分布在两个物种中均显示出可比的结果。共聚焦成像显示，VGLUT1免疫反应性（-ir）与肌性神经纤维内以及胆碱能和硝化性肌层神经元细胞体内的胆碱能和硝酸能/肽能标记物存在大量共定位。 VGLUT1和胆碱能标记也已在肌层粘膜纤维中共定位，而VGLUT1和硝化能标记从未在肌层粘膜纤维中共定位，尽管这确实发生在通向运动终板的肌层纤维中。因此，VGLUT1包含在小鼠食道运动终板的硝化神经支配中，这与大鼠食道的另一个不同之处。因此，VGLUT1-ir存在于小鼠食道的外在和内在神经支配中，但是与大鼠的显着差异表明与VGLUT在外周神经系统中的分布有关的物种变异。

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