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首页> 外文期刊>Cell and Tissue Research >Immunohistological markers for staging neurogenesis in adult hippocampus
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Immunohistological markers for staging neurogenesis in adult hippocampus

机译：成年海马神经发生分期的免疫组织学标记

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摘要

Neurogenesis in the adult dentate gyrus (DG) of the hippocampus occurs constitutively throughout postnatal life, and the rate of neurogenesis within the DG can be altered under various physiological and pathophysiological conditions. Adult neurogenesis includes the process in which the division of a precursor cell takes place and the multi-step process (proliferation, differentiation, migration, targeting, and synaptic integration) that ends with the formation of a postmitotic functionally integrated new neuron. During specific time-frames of adult neurogenesis, various markers are expressed that correlate with the differentiation steps along the pathway from early progenitor cells to newly generated postmitotic neurons within the DG. Markers that are currently widely used for the investigation of adult hippocampal neurogenesis are: glial fibrillary acidic protein, nestin, Pax6, NeuroD, PSA-NCAM, doublecortin, TUC-4, Tuj-1, and calretinin. The discovery and development of specific markers that allow the time-course and fate of neurons to be followed during adult neurogenesis in a detailed and precise fashion are not only helpful for gaining further insights into the genesis of new neurons in the hippocampus, but also might be applicable to the development of strategies for therapeutic interventions.
机译：在整个出生后的生活中，海马的成年齿状回（DG）中的神经发生组成性发生，并且在各种生理和病理生理条件下，DG中的神经发生速率可以改变。成人神经发生包括前体细胞分裂的过程和以有丝分裂后功能整合的新神经元形成为结束的多步过程（增殖，分化，迁移，靶向和突触整合）。在成年神经发生的特定时间范围内，表达各种标志物，这些标志物与从早期祖细胞到DG中新产生的有丝分裂后神经元的途径中的分化步骤相关。当前广泛用于研究成年海马神经发生的标志物是：神经胶质纤维酸性蛋白，巢蛋白，Pax6，NeuroD，PSA-NCAM，双皮质素，TUC-4，Tuj-1和钙黄蛋白。特定标记物的发现和发展，使成人神经发生过程中神经元的时程和命运得以详细而精确地跟踪，不仅有助于进一步了解海马中新神经元的起源，而且还可能适用于治疗干预策略的制定。

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