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首页> 外文期刊>Cell and Tissue Research >Distribution of Notch protein members in normal and preeclampsia-complicated placentas
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Distribution of Notch protein members in normal and preeclampsia-complicated placentas

机译：Notch蛋白成员在正常子痫前期胎盘中的分布

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摘要

Notch proteins are a transmembrane receptor family that is structurally and functionally conserved from worms to humans. The mammalian family of Notch proteins consists of several genes encoding Notch receptors and related Notch ligands. Notch signaling is involved in different aspects of the cell-fate decision tree: differentiation, proliferation, and apoptosis. These three processes are finely regulated in human placenta in order to allow a successful pregnancy and correct fetal growth. Notch and its ligands also participate in vascular remodeling and stabilization. Vasculogenesis and blood regulation are of importance in the human placenta for normal fetal development and growth; any disorder of these systems leads to preeclampsia. Drawing on this background, we have investigated the expression of Notch-1, Notch-4, and Jagged-1, together with two members related to the Notch pathway in angiogenesis: VEGF and p21. Normal and preeclamptic human placentas have been evaluated by immunohistochemistry. In preeclamptic samples, a down-regulation of Notch pathway members occurs with a weak/moderate expression of the Notch protein members in all components of placenta compared with physiological placentas that, at term, exhibit the strong expression of Jagged-1 and a moderate expression of both Notch-1 and Notch-4 in all compartments of the placental villi. Moreover, preeclamptic samples also reveal a down-regulation of VEGF expression, together with a moderate nuclear expression of p21Cip1 in the syncytiotrophoblast, cytotrophoblast, and endothelial cells. This down-regulation of VEGF in preeclamptic placentas, in turn, probably decreases Notch protein expression in placental compartments and in endothelial cells and could offer an ethiopathogenetic explanation for the onset of this pathology.
机译：Notch蛋白是一个跨膜受体家族，从蠕虫到人类在结构和功能上都是保守的。 Notch蛋白的哺乳动物家族由编码Notch受体和相关Notch配体的几个基因组成。 Notch信号传导参与细胞命运决策树的不同方面：分化，增殖和凋亡。这三个过程在人胎盘中都得到了很好的调节，从而可以成功怀孕并纠正胎儿的生长。 Notch及其配体也参与血管重塑和稳定。血管生成和血液调节对于人胎盘对胎儿的正常发育至关重要。这些系统的任何障碍都会导致先兆子痫。在此背景下，我们研究了Notch-1，Notch-4和Jagged-1的表达以及与血管生成中的Notch途径有关的两个成员：VEGF和p21。正常和子痫前期人胎盘已通过免疫组织化学评估。在子痫前期样品中，Notch通路成员的下调发生在胎盘的所有组件中，Notch蛋白成员的表达弱/中等，而生理学胎盘则表现出Jagged-1的强表达和中等的表达。在胎盘绒毛的所有隔室中同时插入Notch-1和Notch-4。此外，先兆子痫样品还显示合体滋养层细胞，滋养细胞和内皮细胞中VEGF表达下调，同时p21Cip1 呈中等程度的核表达。子痫前期胎盘中VEGF的这种下调反过来可能会降低胎盘区室和内皮细胞中Notch蛋白的表达，并可能为这种病理的发病提供电子病因解释。

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  • 来源
    《Cell and Tissue Research》 |2007年第3期|527-534|共8页
  • 作者

    Luigi Cobellis; Annunziata Mastrogiacomo; Elisabetta Federico; Maria Teresa Schettino; Maria De Falco; Lucrezia Manente; Gabriele Coppola; Marco Torella; Nicola Colacurci; Antonio De Luca;

  • 作者单位

    Department of Gynaecology Obstetric and Reproductive Science Second University of Naples Naples Italy;

    Department of Gynaecology Obstetric and Reproductive Science Second University of Naples Naples Italy;

    Department of Gynaecology Obstetric and Reproductive Science Second University of Naples Naples Italy;

    Department of Gynaecology Obstetric and Reproductive Science Second University of Naples Naples Italy;

    Department of Biological Sciences Section of Evolutionary and Comparative Biology University of Naples “Federico II” Naples Italy;

    Department of Medicine and Public Health Section of Human Anatomy Second University of Naples Via L. Armanni 5 80138 Naples Italy;

    Department of Medicine and Public Health Section of Human Anatomy Second University of Naples Via L. Armanni 5 80138 Naples Italy;

    Department of Gynaecology Obstetric and Reproductive Science Second University of Naples Naples Italy;

    Department of Gynaecology Obstetric and Reproductive Science Second University of Naples Naples Italy;

    Department of Medicine and Public Health Section of Human Anatomy Second University of Naples Via L. Armanni 5 80138 Naples Italy;

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  • 正文语种 eng
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  • 关键词

    Placenta; Preeclampsia; Notch pathway; Angiogenesis; Immunohistochemistry; Human;

    机译：胎盘;先兆子痫;Notch途径;血管生成;免疫组化;人类;

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