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首页> 外文期刊>CEN Case Reports >Combined membranous nephropathy and crescentic glomerulonephritis with concurrent anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody
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Combined membranous nephropathy and crescentic glomerulonephritis with concurrent anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody

机译：合并膜性肾病和新月型肾小球肾炎并发抗肾小球基底膜抗体和髓过氧化物酶特异性抗中性粒细胞胞浆抗体

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摘要

We report a case of a 71-year-old man with rapidly progressive nephritic syndrome and dual positivity for anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody. Renal biopsy revealed crescentic, mainly cellular, glomerulonephritis with granulomatous lesions, and advanced membranous changes. Membranous nephropathy had apparently existed for an extended period before the development of crescentic glomerulonephritis. In some studies reporting the simultaneous occurrence of both diseases, membranous nephropathy might be followed by crescentic glomerulonephritis, presumably from a histological point of view. Although we cannot prove a causal relationship between the two diseases, we caution that precise observations, especially histological, are necessary in similar cases.
机译：我们报告一例71岁男子，患有迅速进行性肾病综合征，抗肾小球基底膜抗体和髓过氧化物酶特异性抗中性粒细胞胞浆抗体双重阳性。肾活检显示为新月形，主要是细胞性肾小球肾炎，伴肉芽肿性病变和晚期膜性改变。膜性肾病在新月型肾小球肾炎发展之前已经存在了很长一段时间。在一些报道两种疾病同时发生的研究中，从组织学的角度来看，膜状肾病可能伴有新月形肾小球肾炎。尽管我们无法证明这两种疾病之间存在因果关系，但我们提醒您，在类似情况下，必须进行精确观察，尤其是组织学观察。

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