• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>CEN Case Reports >A case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lupus erythematosus in the central nervous system
【24h】

A case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lupus erythematosus in the central nervous system

机译：中枢神经系统红斑狼疮患者抗利尿激素分泌异常综合征（SIADH）一例

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We report on a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lupus erythematosus in the central nervous system (CNS). A 73-year-old woman with essential hypertension suddenly demonstrated consciousness disturbance. Upon her admission, laboratory data showed significant hyponatremia (114 mEq/L) and a lack of body fluid loss. Diminished free water excretion (urine osmolality 684 mOsm/kg) and normal urine Na excretion (FENa 1.70 %) were consistent with the diagnosis of SIADH, which was confirmed by an inappropriately high concentration of plasma antidiuretic hormone (ADH) (15.3 pg/mL at 256 mOsm/kg of plasma osmolality). The hyponatremia was corrected by a combination of oral water intake restriction and saline infusion with furosemide administration until the 20th hospital day. Simultaneously, the presence of exudative pleural effusion in both chest cavities, suggesting the existence of pleuritis, and high titer of anti-nuclear antibody (ANA, 5120×) and anti-double-strand DNA antibody (6500 IU/mL), indicated the subclinical development of systemic lupus erythematosus (SLE), although the diagnostic criteria were not satisfied at that time. On the 34th hospital day, the sudden onset of unknown consciousness disturbance confirmed the diagnosis of SLE as CNS lupus. In previous case reports on SLE and/or SIADH, a few cases in which SLE and SIADH developed concomitantly regularly showed high immunological activities, as in our case. Some common pathophysiological bases might be involved in the concomitant appearance of those disorders.
机译：我们报告一例与中枢神经系统（CNS）红斑狼疮相关的抗利尿激素（SIADH）分泌不当综合征。一名73岁的原发性高血压妇女突然表现出意识障碍。她入院后，实验室数据显示严重低钠血症（114 mEq / L）和体液缺乏。游离水排泄减少（尿渗透压为684mOsm / kg）和正常尿液Na排泄（FENa为1.70％）与SIADH的诊断一致，血浆抗利尿激素（ADH）浓度过高（15.3 pg / mL）证实了这一点。在256摩尔渗透压/千克血浆渗透压下）。通过限制口服水摄入量和盐水输注与速尿联合使用来纠正低钠血症，直到第20个医院工作日。同时，两个胸腔中都存在渗出性胸腔积液，表明存在胸膜炎，并且抗核抗体（ANA，5120×）和抗双链DNA抗体（6500IU / mL）的滴度高。系统性红斑狼疮（SLE）的亚临床发展，尽管当时诊断标准还不满足。在医院的第34天，突然出现未知意识障碍，证实了SLE的诊断为CNS狼疮。在以前的关于SLE和/或SIADH的病例报告中，与我们的病例一样，SLE和SIADH伴随发展的少数病例表现出很高的免疫活性。这些疾病的同时出现可能涉及一些常见的病理生理基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号