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首页> 外文期刊>CEN Case Reports >Pulmonary and gastric metastatic calcification due to milk-alkali syndrome: a case report
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Pulmonary and gastric metastatic calcification due to milk-alkali syndrome: a case report

机译：牛奶碱综合症引起的肺和胃转移性钙化：一例报告

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The incidence of metastatic calcification is influenced by high serum calcium and phosphate concentrations and local physicochemical conditions, such as pH. A high pH accelerates tissue calcification. Patients with milk-alkali syndrome typically present with renal failure, hypercalcemia, and metabolic alkalosis, which are caused by the ingestion of calcium and absorbable alkali. Among patients with impairment of renal function, milk-alkali syndrome is a major cause of hypercalcemia. Long-term use of furosemide will lead to hypokalemia, metabolic alkalosis, and eventually renal failure (i.e., pseudo-Bartter syndrome). Even if the level of calcium ingestion is relatively low, the renal failure caused by long-term furosemide use can readily lead to milk-alkali syndrome. We describe a case of a 45-year-old woman who was admitted with cough and dyspnea and presented with pulmonary and gastric metastatic calcification. She had been taking alfacalcidol and oral alkaline medications such as sodium bicarbonate and calcium carbonate as well as oral furosemide for a long time. The patient was found to have hypercalcemia, chronic renal failure, and metabolic alkalosis, so milk-alkali syndrome was diagnosed. Saline was administered and oral medications were discontinued. Serum creatinine levels subsequently decreased, but pulmonary metastatic calcification was not diminished. In this case, the milk-alkali syndrome that caused the severe metastatic calcification was exacerbated by multiple factors, including oral alkaline medications such as sodium bicarbonate and calcium carbonate. In addition, metabolic alkalosis and renal failure were affected by long-term furosemide use (i.e., pseudo-Bartter syndrome).
机译：转移性钙化的发生率受血清钙和磷酸盐浓度高以及局部理化条件（例如pH）的影响。高pH值会加速组织钙化。牛奶碱综合症患者通常表现为肾功能衰竭，高钙血症和代谢性碱中毒，这是由于摄入钙和可吸收的碱引起的。在肾功能受损的患者中，牛奶碱综合症是高钙血症的主要原因。长期使用速尿会导致低血钾，代谢性碱中毒并最终导致肾功能衰竭（即假性Bartter综合征）。即使钙的摄入量相对较低，长期使用速尿导致的肾功能衰竭也很容易导致牛奶碱综合症。我们描述了一个病例，该例为一名45岁的妇女，因咳嗽和呼吸困难入院，并出现了肺和胃转移性钙化。她长期服用阿尔法骨化醇和口服碱性药物，例如碳酸氢钠和碳酸钙，以及口服速尿。该患者被发现患有高钙血症，慢性肾功能衰竭和代谢性碱中毒，因此被诊断出牛奶碱综合症。给予生理盐水，并停止口服药物。血清肌酐水平随后下降，但肺转移钙化并没有减少。在这种情况下，导致严重转移性钙化的牛奶碱综合症会因多种因素而加剧，包括口服碱性药物（如碳酸氢钠和碳酸钙）。此外，长期使用速尿会影响代谢性碱中毒和肾功能衰竭（即伪巴特综合征）。

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