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首页> 外文期刊>CEN Case Reports >Efficacy of tocilizumab, a humanized neutralizing antibody against interleukin-6 receptor, in progressive renal injury associated with Castleman's disease
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Efficacy of tocilizumab, a humanized neutralizing antibody against interleukin-6 receptor, in progressive renal injury associated with Castleman's disease

机译：抗人白介素6受体的人源化中和抗体tocilizumab在与Castleman病相关的进行性肾损伤中的功效

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摘要

Castleman's disease is a benign lymphoproliferative disorder in which interleukin-6 (IL-6), a pleiotropic proinflammatory cytokine, is thought to play a pathogenetic role. Presented is the case of a 72-year-old man with Castleman's disease who exhibited progressive renal dysfunction with proteinuria. Renal biopsy revealed mesangial hypercellularity and matrix expansion in most glomeruli and peritubular inflammatory cell infiltration. Immunofluorescence studies showed intense deposition of IgG in a granular pattern along the glomerular basement membrane. Histological features were compatible with membranoproliferative glomerulonephritis accompanied by interstitial inflammatory cell infiltration. Immunohistological analysis showed that IL-6 was abundantly expressed by tubular cells and interstitial macrophages, suggesting involvement of IL-6 in the renal injury. As a result of administration of tocilizumab, a humanized anti-IL-6 receptor antibody, the patient experienced clinical and biochemical improvement of Castleman's disease, including marked reduction of proteinuria and stabilization of renal function. These findings suggest the efficacy of tocilizumab against Castleman's disease and its renal complications.
机译：Castleman病是一种良性淋巴增生性疾病，其中白细胞介素6（IL-6）是一种多效促炎性细胞因子，被认为具有致病作用。介绍的是一个72岁的患有Castleman病的人，该人表现出进行性肾功能不全伴蛋白尿。肾活检显示大多数肾小球和肾小管周围炎性细胞浸润中系膜细胞增生和基质扩张。免疫荧光研究显示，IgG沿肾小球基底膜呈颗粒状强烈沉积。组织学特征与膜增生性肾小球肾炎伴有间质性炎性细胞浸润相适应。免疫组织学分析显示，IL-6在肾小管细胞和间质巨噬细胞中大量表达，提示IL-6参与了肾损伤。由于给予人源化抗IL-6受体抗体tocilizumab，该患者在临床和生化方面改善了Castleman病，包括蛋白尿明显减少和肾功能稳定。这些发现表明托珠单抗抗Castleman病及其肾脏并发症的功效。

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