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首页> 外文期刊>Central Nervous System Agents in Medicinal Chemistry >Unique Insights into the Actions of CNS Agents: Lessons from Studies of Chlorpyrifos and Other Common Pesticides
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Unique Insights into the Actions of CNS Agents: Lessons from Studies of Chlorpyrifos and Other Common Pesticides

机译：对中枢神经系统药物作用的独特见解：毒死rif和其他常见农药的研究教训

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摘要

The development of CNS drugs has been the most challenging task in drug design. Only an abysmal one percent of nervous system drugs tested in human clinical trials ever reach market. This is largely attributable to the difficulties in both identifying appropriate targets and in understanding the toxicology, pharmacology, and pharmaceutical properties of therapeutic compounds. Pesticides have not attracted much attention in the field of CNS drug design. However, the toxicological and molecular actions of certain pesticides, such as chlorpyrifos and pyrethroids, have been well studied. Furthermore, recent epidemiological data have provided important insights into the actions of pesticides in the human brain. Therefore, in this review we seek to examine and summarize the toxicological and molecular actions of common pesticides, organophosphates and pyrethroids. We will also summarize and compare the effects of common pesticides on the neurological functions in animals and in humans. Common pesticides have been shown to act on molecular targets such as the serotonin receptors, brain-derived neurotrophic factor (BDNF), and the transcription factor CREB. Likewise, pesticides can affect multiple neurological functions, such as motor coordination, habituation, attention, cognition, and psychomotor development. A comprehensive review of the toxicological and molecular roles of pesticides in the CNS might provide insights into the actions of CNS agents.
机译：中枢神经系统药物的开发一直是药物设计中最具挑战性的任务。在人类临床试验中测试的神经系统药物中，只有极低的百分之一进入市场。这主要归因于在确定合适的靶标以及理解治疗化合物的毒理学，药理学和药物特性方面的困难。农药在中枢神经系统药物设计领域没有引起太多关注。但是，已经对某些农药（如毒死rif和拟除虫菊酯）的毒理学和分子作用进行了深入研究。此外，最新的流行病学数据已经提供了有关农药在人脑中的作用的重要见解。因此，在这篇综述中，我们试图研究和总结常见农药，有机磷酸盐和拟除虫菊酯的毒理学和分子作用。我们还将总结并比较常见农药对动物和人类神经功能的影响。常见的农药已显示出对诸如血清素受体，脑源性神经营养因子（BDNF）和转录因子CREB的分子靶标起作用。同样，农药会影响多种神经功能，例如运动协调，习惯，注意力，认知和心理运动发育。对农药在中枢神经系统中的毒理学和分子作用的全面综述可能提供对中枢神经系统药剂作用的见解。

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