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首页> 外文期刊>Cerebral Cortex >Inactivation of the Somatosensory Cortex Prevents Paroxysmal Oscillations in Cortical and Related Thalamic Neurons in a Genetic Model of Absence Epilepsy
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Inactivation of the Somatosensory Cortex Prevents Paroxysmal Oscillations in Cortical and Related Thalamic Neurons in a Genetic Model of Absence Epilepsy

机译：体感皮层的失活防止皮质和相关丘脑神经元的阵发性振荡在缺乏癫痫症的遗传模型中。

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摘要

Absence seizures consist of bilateral spike-and-wave discharges (SWDs) occurring over widespread cortical and thalamic regions. In genetic models of absence epilepsy, recent in vivo investigations indicate that SWDs emerge first in the facial somatosensory cortex and then propagate via the corticothalamocortical loop. The specific involvement of this cortical region in ictogenic processes remained to be established and the participation of its related thalamocortical system in seizure initiation remained unclear. Here, using electrocorticographic (ECoG) and intracellular recordings in vivo from cortex and thalamus in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS), we obtained novel evidence for the cortical focus theory of absence epilepsy. We report that blockade of action potential discharge and synaptic activities in facial somatosensory cortical neurons, by topical application of tetrodotoxin, prevents the occurrence of paroxysmal activities in local and distant cortical neurons and ECoGs, as well as in thalamocortical neurons in register with the somatosensory cortex. In contrast, pharmacological inhibition of a remote motor cortical region or of the related thalamic nuclei did not suppress ictal activities in the somatosensory cortex. This study demonstrates that SWDs in GAERS have a focal origin within the facial somatosensory cortex, which is sufficient and necessary to generate ictal activities.
机译：失神发作包括在广泛的皮层和丘脑区域发生的双边尖峰波放电（SWD）。在没有癫痫病的遗传模型中，最近的体内研究表明，SWD首先出现在面部体感皮层中，然后通过皮层-皮质-皮层环传播。该皮质区域是否参与致癌过程仍有待确定，其相关的丘脑皮质系统是否参与癫痫发作尚不清楚。在这里，使用电皮质醇（ECoG）和来自史特拉斯堡的遗传性缺乏癫痫大鼠（GAERS）中皮质和丘脑的体内细胞内记录，我们获得了缺乏癫痫病的皮层聚焦理论的新证据。我们报告说，通过局部应用河豚毒素可阻断面部体感皮层神经元的动作电位放电和突触活动，可防止局部和远处皮层神经元和ECoGs以及在与体感皮层注册的丘脑皮层神经元发生阵发性活动。 。相反，药理学上对远端运动皮层区域或相关丘脑核的抑制作用并不能抑制体感皮层中的短暂活动。这项研究表明，GAERS中的SWD起源于面部躯体感觉皮层内，这是充分和必要的，可以产生短暂的活动。

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    《Cerebral Cortex》 |2009年第9期|p.2078-2091|共14页
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    Pierre-Olivier Polack12 Séverine Mahon12 Mario Chavez3 and Stéphane Charpier124;

  • 作者单位

    1INSERM UMR_S 667, Dynamique et Physiopathologie des Réseaux Neuronaux, F-75005 Paris, France 2Collège de France, UMR_S 667, F-75005 Paris, France 3Laboratoire de Neurosciences Cognitives &

    Imagerie Cérébrale, CNRS UPR 640 – LENA, 75651 Paris Cedex 13, France 4UPMC Univ Paris 06, UMR_S 667, F-75005 Paris, France;

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