SEEING CISPLATIN

SARAH EVERTS

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SEEING CISPLATIN

机译：查看西斯拉汀

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Cisplatin has been used to treat cancer for decades. But the drug's detailed molecular interactions with the enzymes it aims to interrupt have remained obscure. In two separate papers, researchers are now reporting the first crystal structures of cisplatin complexed with two key enzymes. "For the first time, we are getting deep insight on what goes on at the atomic level with cisplatin and cellular machinery," says Thomas Carell, a protein chemist at the University of Munich.

机译：顺铂用于治疗癌症已有数十年的历史了。但是，该药物与其旨在打断的酶之间的详细分子相互作用仍然不清楚。在两篇不同的论文中，研究人员现在报告与两种关键酶复合的顺铂的第一个晶体结构。慕尼黑大学的蛋白质化学家托马斯·卡雷尔（Thomas Carell）表示：“我们首次对顺铂和细胞机械在原子水平上的变化有了深刻的了解。”

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《Chemical & Engineering News》 |2007年第46期|p.13|共1页
作者
SARAH EVERTS;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类化学工业;化学;
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1. A randomised phase II trial of capecitabine plus cisplatin versus S-1 plus cisplatin as a first-line treatment for advanced gastric cancer: Capecitabine plus cisplatin ascertainment versus S-1 plus cisplatin randomised PII trial (XParTS II) [J] . Nishikawa Kazuhiro, Tsuburaya Akira, Yoshikawa Takaki, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2018,第期

机译：Capecitabine Plus顺铂的随机期II试验与S-1加顺铂作为晚期胃癌的一线治疗：Capecitabine Plus顺铂确定与S-1加上顺铂随机化PII试验（XParts II）
2. Gemcitabine and cisplatin versus vinorelbine and cisplatin versus ifosfamide+gemcitabine followed by vinorelbine and cisplatin versus vinorelbine and cisplatin followed by ifosfamide and gemcitabine in stage IIIB-IV non small cell lung carcinoma: a p [J] . Gebbia V, Galetta D, Caruso M, Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2003,第2期

机译：在IIIB-IV期非小细胞肺癌中，吉西他滨和顺铂对长春瑞滨和顺铂对异环磷酰胺+吉西他滨，然后长春瑞滨和顺铂对长春瑞滨和顺铂，然后异环磷酰胺和吉西他滨对非小细胞肺癌
3. Long-term outcomes with intensive induction chemotherapy (carboplatin, bleomycin, vincristine and cisplatin/bleomycin, etoposide and cisplatin) and standard bleomycin, etoposide and cisplatin in poor prognosis germ cell tumours: A randomised phase II trial (ISRCTN53643604) [J] . Cafferty Fay H., White Jeff D., Shamash Jonathan, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2020,第期

机译：具有强化诱导化疗的长期成果（卡铂，博尔霉素，长霉素和顺铂，依托磷脂和顺铂）和标准博来霉素，依托磷脂在预后差异细胞肿瘤中的标准博霉素：随机期II试验（ISRCTN53643604）
4. EFFECT OF THE NOVEL CHEMOPROTECTANT DRUG, TAVOCEPT~(TM), ON IN VITRO CYTOTOXICITY OF CISPLATIN AND CISPLATIN/PIROXICAM COMBINATION THERAPY AGAINST CANINE TRANSITIONAL CELL CARCINOMA OF THE BLADDER [C] . Carolyn Henry, Aulma Parker, Min Zhao, Annual Conference of the Veterinary Cancer Society . 2009

机译：新型化学防护药物，Tavopect〜（TM）的影响，对顺铂和顺铂/吡洛昔康组合治疗膀胱犬转型细胞癌的体外细胞毒性
5. Electronic Cigarettes: Implications on Cancer Risk and Cisplatin Resistance in Oral Epithelial Cells [D] . Manyanga, Jimmy. 2020

机译：电子香烟：对口腔上皮细胞的癌症风险和顺铂抗性的影响
6. Upregulated expression of BCL2 MCM7 and CCNE1 indicate cisplatin-resistance in the set of two human bladder cancer cell lines: T24 cisplatin sensitive and T24R2 cisplatin resistant bladder cancer cell lines [O] . Sung Han Kim, Jin-Nyoung Ho, Hyunjin Jin, 2016

机译：BCL2MCM7和CCNE1的表达上调表明在两种人膀胱癌细胞系：T24顺铂敏感性和T24R2顺铂抵抗性膀胱癌细胞系中顺铂耐药
7. 269MO Comparison of three induction chemotherapy regimens with gemcitabine plus cisplatin, cisplatin plus fluorouracil, and cisplatin plus capecitabine for locoregionally advanced nasopharyngeal carcinoma: A pooled analysis of two prospective studies [O] . S.K. Chan, C.W. Choi, S.Y. Chan, 2020

机译：269Mo比较吉西滨加甘胺，顺铂加氟尿嘧啶，顺铂加上卡西布汀的三种诱导化疗方案对型鼻咽癌癌症癌：两个前瞻性研究的汇总分析

SEEING CISPLATIN

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