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首页> 外文期刊>Chemical Research in Chinese Universities >A Convenient and Easy-controlled Method for Preparation of 7,10-Bis(2,2,2-trichloroethyloxycarbonyl)-10-deacetyl Baccatin III
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A Convenient and Easy-controlled Method for Preparation of 7,10-Bis(2,2,2-trichloroethyloxycarbonyl)-10-deacetyl Baccatin III

机译:一种方便易控制的7,10-双(2,2,2-三氯乙氧基羰基)-10-去乙酰基浆果赤霉素III的制备方法

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摘要

The complex natural product paclitaxel (Tax-ol,1a),first isolated from Taxus brevifolia,has an excellent clinical activity against ovarian and breast cancers and shows promising results in the treatment of other cancers.The structure-activity relationships (SAR) of taxoid derivatives have been extensively studied to search for the analogues bearing better physical,chemical and biological properties.One example is the discovery of Taxotere(lb).The structures of Taxol and Tax-otere are shown in Scheme 1.
机译:紫杉醇(Tax-ol,1a)是一种复杂的天然产物,首次从短叶红豆杉中分离出来,对卵巢癌和乳腺癌具有出色的临床活性,在治疗其他癌症方面显示出令人鼓舞的结果。衍生物已被广泛研究以寻找具有更好的物理,化学和生物学特性的类似物.Taxotere(lb)的发现就是一个例子.Taxol和Taxotere的结构如方案1所示。

著录项

  • 来源
    《Chemical Research in Chinese Universities》 |2004年第6期|p.813-816|共4页
  • 作者单位

    School of Chemical Engineering,Dalian University of Technology,Dalian 116012,P.R.China;

    Information College of Science and Technology,Nanjing Forestry University,Nanjing 210037,P.R.China;

    State Key Laboratory of Coordination Chemistry,Coordination Chemistry Institute,Nanjing University,Nanjing 210093,P.R.China;

    State Key Laboratory of Coordination Chemistry,Coordination Chemistry Institute,Nanjing University,Nanjing 210093,P.R.China;

    State Key Laboratory of Coordination Chemistry,Coordination Chemistry Institute,Nanjing University,Nanjing 210093,P.R.China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    2; 2; 2-Trichloroethylchloroformate; 10-Deacetyl baccatin III; Coupling reaction;

    机译:2;2;2-三氯乙基氯甲酸酯;10-脱乙酰浆果赤霉素III;偶联反应;

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