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Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish

机译：聚苯乙烯微塑料对斑马鱼幼体微生物组组成和代谢的影响

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Microplastics are major pollutants in marine environment and may have health effects on aquatic organisms. In this study, we used two sizes (5 and 50 mu m diameter) of fluorescent and virgin polystyrene microplastics to analyze the adverse effects on larval zebrafish. In our study, we evaluated the effects on larval zebrafish after exposure to 100 and 1000 mu g/L of two sizes of polystyrene microplastics for 7 days. Our results show that polystyrene microplastics could cause alterations in the microbiome at the phylum and genus levels in larval zebrafish, including changes in abundance and diversity of the microbiome. In addition, metabolomic analysis suggested that exposure to polystyrene microplastics induced alterations of metabolic profiles in larval zebrafish, and differential metabolites were involved in energy metabolism, glycolipid metabolism, inflammatory response, neurotoxic response, nucleic acid metabolism, oxidative stress. Polystyrene microplastics also significantly decreased the activities of catalase and the content of glutathione. In addition, the results of gene transcription analysis showed that exposure to polystyrene microplastics induced changes in glycolysis-related genes and lipid metabolism-related genes, confirming that polystyrene microplastics disturbed glycolipid and energy metabolism. Taken together, the results obtained in the present study indicated that the potential effects of environmental microplastics on aquatic organisms should not be ignored. (C) 2018 Elsevier Ltd. All rights reserved.
机译：微塑料是海洋环境中的主要污染物，可能对水生生物产生健康影响。在这项研究中，我们使用了两种尺寸（直径分别为5和50微米）的荧光和纯聚苯乙烯微塑料来分析对幼虫斑马鱼的不利影响。在我们的研究中，我们评估了在100和1000μg / L两种尺寸的聚苯乙烯微塑料中暴露7天后对幼虫斑马鱼的影响。我们的研究结果表明，聚苯乙烯微塑料可能会导致幼虫斑马鱼的菌群和属水平的微生物组发生变化，包括微生物组的丰度和多样性发生变化。此外，代谢组学分析表明，暴露于聚苯乙烯微塑料中会引起斑马鱼幼虫的代谢特征发生变化，并且不同的代谢产物参与能量代谢，糖脂代谢，炎症反应，神经毒性反应，核酸代谢，氧化应激。聚苯乙烯微塑料还显着降低了过氧化氢酶的活性和谷胱甘肽的含量。另外，基因转录分析的结果表明，暴露于聚苯乙烯微塑料会引起糖酵解相关基因和脂质代谢相关基因的变化，从而证实聚苯乙烯微塑料会干扰糖脂和能量代谢。综上所述，本研究获得的结果表明，环境微塑料对水生生物的潜在影响不容忽视。 （C）2018 Elsevier Ltd.保留所有权利。

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