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首页> 外文期刊>Chemosphere >Characterization of leachates from waste landfill sites in a religious camp along Lagos-Ibadan expressway, Nigeria and its hepatotoxicity in rats
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Characterization of leachates from waste landfill sites in a religious camp along Lagos-Ibadan expressway, Nigeria and its hepatotoxicity in rats

机译：尼日利亚拉各斯-伊巴丹高速公路沿一条宗教营地的垃圾掩埋场渗滤液的表征及其对大鼠的肝毒性

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Landfill sites near human settlements are known to have adverse health effects. Here, we investigated the effect of different concentrations of leachates from the Redemption Camp landfill (RCLL, 10%, 30%, 50%) on the liver of adult female rats after 21 days of exposure in their drinking water. The physicochemical and metal analyses showed that biochemical oxygen and chemical oxygen demand, zinc and magnesium levels were significantly high, whereas copper level was low in RCLL when compared to water samples from residential areas close to the landfill site, and were higher than the acceptable limits (p 0.05). The predominant bacteria isolates recovered from the leachate and drinking water samples were Escherichia coli, Salmonella spp and Shigella spp. At the end of the 21-day exposure, RCLL increased the weight of the liver. Malondialdehyde concentrations were increased and glutathione levels were decreased significantly in the liver of treated animals at all concentrations of leachates tested. Furthermore, the activities of serum alanine amino transferase, aspartate amino transferase, gamma glutamyl transferase and cholesterol concentrations were increased whereas bilirubin and albumin levels were decreased dose-dependently. Histological examination of the liver was characterized by accumulation of inflammatory cells around hepatocytes, and extended sinusoids. The histo-pathological alterations and oxidative damage observed in the liver of treated rats and occurrence of pathogenic species and metals in the RCLL may suggest possible impaired hepatic health in subjects with occupational or environmental exposure. (C) 2018 Elsevier Ltd. All rights reserved.
机译：众所周知，人类住区附近的垃圾填埋场会对健康产生不利影响。在这里，我们研究了成年雌性大鼠在饮用水中接触21天后，来自救赎营填埋场（RCLL，10％，30％，50％）不同浓度的渗滤液对成年大鼠肝脏的影响。物理化学和金属分析表明，与来自垃圾填埋场附近居民区的水样相比，RCLL中的生化需氧量和化学需氧量，锌和镁含量显着较高，而铜的含量较低（p ＜0.05）。从渗滤液和饮用水样品中回收的主要细菌分离株为大肠杆菌，沙门氏菌和志贺氏菌。在21天的暴露结束时，RCLL增加了肝脏的重量。在所有测试的浸出液浓度下，治疗动物的肝脏中丙二醛浓度均升高，谷胱甘肽水平显着降低。此外，血清丙氨酸氨基转移酶，天冬氨酸氨基转移酶，γ-谷氨酰转移酶和胆固醇的活性呈剂量依赖性增加，而胆红素和白蛋白水平呈下降趋势。肝脏的组织学检查的特征是肝细胞周围炎性细胞的积累和正弦曲线的扩展。在治疗大鼠的肝脏中观察到的组织病理学变化和氧化损伤以及RCLL中病原体和金属的出现可能表明职业或环境暴露的受试者可能会损害肝脏健康。 （C）2018 Elsevier Ltd.保留所有权利。

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