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首页> 外文期刊>Chemosphere >Co-selection of multi-antibiotic resistance in bacterial pathogens in metal and microplastic contaminated environments: An emerging health threat
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Co-selection of multi-antibiotic resistance in bacterial pathogens in metal and microplastic contaminated environments: An emerging health threat

机译：金属和微塑料污染环境中细菌病原体中多种抗生素耐药性的共同选择：对健康的新威胁

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Misuse/over use of antibiotics increases the threats to human health since this is a main reason behind evolution of antibiotic resistant bacterial pathogens. However, metals such as mercury, lead, zinc, copper and cadmium are accumulating to critical concentration in the environment and triggering co-selection of antibiotic resistance in bacteria. The co-selection of metal driven antibiotic resistance in bacteria is achieved through co-resistance or cross resistance. Metal driven antibiotic resistant determinants evolved in bacteria and present on same mobile genetic elements are horizontally transferred to distantly related bacterial human pathogens. Additionally, in marine environment persistent pollutants like microplastics is recognized as a vector for the proliferation of metal/antibiotics and human pathogens. Recently published research confirmed that horizontal gene transfer between phylogenetically distinct microbes present on microplastics is much faster than free living microbes. Therefore, micro plastics act as an emerging hotspot for metal driven co-selection of multidrug resistant human pathogens and pose serious threat to humans which do recreational activities in marine environment and ingest marine derived foods. Therefore, marine environment co-polluted with metal, antibiotics, human pathogens and microplastics pose an emerging health threat globally. (C) 2018 Elsevier Ltd. All rights reserved.
机译：滥用/滥用抗生素会增加对人体健康的威胁，因为这是产生抗生素抗药性细菌病原体的主要原因。但是，诸如汞，铅，锌，铜和镉之类的金属在环境中积累到临界浓度，并触发了细菌对抗生素抗性的共选。细菌中金属驱动的抗生素耐药性的共选择是通过共耐药性或交叉耐药性实现的。金属驱动的抗生素抗性决定簇在细菌中进化并存在于相同的可移动遗传元件中，被水平转移至远缘相关的细菌人类病原体。另外，在海洋环境中，持久性污染物（如微塑料）被认为是金属/抗生素和人类病原体繁殖的媒介。最近发表的研究证实，在微塑料上存在的系统发育上不同的微生物之间的水平基因转移比游离的活菌快得多。因此，微塑料作为金属驱动的多药耐药性人类病原体共同选择的新兴热点，对在海洋环境中进行娱乐活动并摄入海洋衍生食品的人类构成了严重威胁。因此，海洋环境与金属，抗生素，人类病原体和微塑料共同污染，对全球健康构成了新的威胁。 （C）2018 Elsevier Ltd.保留所有权利。

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