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Cadmium-mediated miR-30a-GRP78 leads to JNK-dependent autophagy in chicken kidney

机译：镉介导的miR-30a-GRP78导致鸡肾依赖JNK的自噬

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摘要

Cadmium-mediated microRNAs have become a heavily researched topic. Few studies mention the regulation of autophagy by cadmium through microRNAs, especially regarding poultry. The kidney is one of the organs most severely affected by cadmium, as it is involved in the accumulation of metal ions; causing such types of damage as apoptosis, necrosis and autophagy to the body. However, the relationship between miR-30a and GRP78 in the chicken kidney during ER stress and autophagy via JNK has not been thoroughly elucidated to date. In our research, we randomly assigned 128 Hy-Line Brown laying chickens to four groups with different diet treatments. The four groups consisted of the control group (0.2 mg Se kg-1), the Se group (2 mg kg-1 of Na2SeO3), the Se + Cd group (150 mg kg-1 of CdCl2 and 2 mg kg-1 of Na2SeO3) and the Cd group (150 mg kg-1 of CdCl2). On the 90th day, we detected the expression of miR-30a, GRP78, ER stress-related genes, IRE-1-JNK and autophagy-related genes. Compared with the control group, the mRNA levels of IRE-1-JNK, ER stress-related genes, autophagy-related genes and GRP78 were significantly increased (P 0.05), while the expression of miR-30a was significantly decreased (p 0.05) in the Cd group. However, those changes were clearly alleviated in the Se + Cd group (p 0.05). In summary, we demonstrated that Cd triggered an miR-30a-GRP78 signaling axis disorder, increasing ER stress and activating the IRE-1-JNK pathway, thereby promoting autophagy in the chicken kidney. Moreover, Se could antagonize the negative impact of Cd. (C) 2018 Elsevier Ltd. All rights reserved.
机译：镉介导的microRNA已成为研究热点。很少有研究提到镉通过微RNA调节自噬，特别是关于家禽。肾脏是受镉影响最严重的器官之一，因为它参与了金属离子的积累。导致诸如细胞凋亡，坏死和自噬等类型的损害。然而，迄今为止，尚未充分阐明内质网应激期间鸡肾中miR-30a和GRP78与通过JNK自噬的关系。在我们的研究中，我们将128只Hy-Line Brown产蛋鸡随机分配到四组采用不同饮食疗法的鸡群。这四组包括对照组（0.2 mg Se kg-1），Se组（2 mg kg-1 Na2SeO3），Se + Cd组（150 mg kg-1 CdCl2和2 mg kg-1 NaCl）。 Na2SeO3）和Cd组（150 mg kg-1 CdCl2）。在第90天，我们检测到miR-30a，GRP78，ER应激相关基因，IRE-1-JNK和自噬相关基因的表达。与对照组相比，IRE-1-JNK，ER应激相关基因，自噬相关基因和GRP78的mRNA水平显着升高（P <0.05），而miR-30a的表达显着降低（p <0.05）。镉组）。但是，Se + Cd组的这些变化明显得到缓解（p <0.05）。总之，我们证明了Cd触发了miR-30a-GRP78信号轴疾病，增加了ER应激并激活了IRE-1-JNK途径，从而促进了鸡肾脏的自噬。此外，硒可以拮抗镉的负面影响。 （C）2018 Elsevier Ltd.保留所有权利。

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  • 来源
    《Chemosphere》 |2019年第1期|710-715|共6页
  • 作者

    Shi Qunxiang; Jin Xi; Fan Ruifeng; Xing Mengyuan; Guo Jinming; Zhang Ziwei; Zhang Junmin; Xu Shiwen;

  • 作者单位

    Northeast Agr Univ, Coll Vet Med, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Coll Vet Med, Dept Heilongjiang Common Anim Dis Prevent & Treat, Key Lab Prov Educ, Harbin 150030, Heilongjiang, Peoples R China;

    Chinese Acad Agr Sci, Sci Observing & Expt Stn Anim Genet Resources & N, Minist Agr, Inst Anim Sci, 2 Yuanmingyuan West Rd Haidian Dist, Beijing 100193, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cadmium; miR-30a-GRP78; JNK; Autophagy; ER stress;

    机译：镉;miR-30a-GRP78;JNK;自噬;内质网应激;

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