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Interaction of nano carbon particles and anthracene with pulmonary surfactant: The potential hazards of inhaled nanoparticles

机译：纳米碳颗粒和蒽与肺表面活性剂的相互作用：吸入纳米颗粒的潜在危害

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Understanding the alteration of the air-liquid interfacial properties of pulmonary surfactant (PS) in the presence of nanoparticles (NPs) and polycyclic aromatic hydrocarbons (PAHs) is particularly important for pulmonary risk assessment. Here, we investigated the interaction of natural PS (extracted from pig's lungs) with nano carbon particles (NCPs) and anthracene as a representative PAH. Our results showed that PS exhibited a significant solubilization effect on anthracene. Solubilization experiment for the substructures of PS demonstrated that the mixed phospholipid components of PS played the primary role in the solubilization of PS for anthracene. Adsorption experiment indicated that in the mixed system of PS, NCPs, and anthracene, PS can inhibit the adsorption of anthracene on NCPs due to the solubilization, agglomeration, and competitive adsorption. In addition, the surface tension, phase behavior, and foaming ability of PS were obviously altered in the presence of NCPs. These findings indicate that the solubilization effect of PS on anthracene, the inhibitive effect of PS for the adsorption of anthracene on NCPs, and the alternation of air-liquid interfacial properties of PS containing NCPs may increase the pulmonary risk in the exposure of atmospheric environment containing both PAHs and NCPs. (C) 2018 Published by Elsevier Ltd.
机译：了解在存在纳米颗粒（NPs）和多环芳烃（PAHs）的情况下肺表面活性剂（PS）的气液界面特性的变化对于肺部风险评估尤为重要。在这里，我们研究了天然PS（从猪肺中提取）与纳米碳颗粒（NCP）和蒽作为代表性PAH的相互作用。我们的结果表明，PS对蒽具有显着的增溶作用。 PS的亚结构的增溶实验表明，PS的混合磷脂成分在PS的蒽增溶中起主要作用。吸附实验表明，在PS，NCP和蒽的混合体系中，PS由于其增溶，团聚和竞争性吸附作用，可以抑制蒽在NCP上的吸附。另外，在存在NCP的情况下，PS的表面张力，相行为和发泡能力明显改变。这些发现表明，PS对蒽的增溶作用，PS对蒽对NCPs的吸附的抑制作用以及含PS的NCP的气液界面性质的改变都可能增加暴露于含NCP的大气中的肺部风险。 PAH和NCP。 （C）2018由Elsevier Ltd.发布

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