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Multiple biomarkers based appraisal of deltamethrin induced toxicity in silver carp (Hypophthalmichthys molitrix)

机译：基于多种生物标记的溴氰菊酯在induced鱼中引起的毒性评估

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Deltamethrin (DLM) is alpha-cyano (type II) synthetic pyrethroid. DLM exposure leads to strong neurotoxic effects and a number of complex toxicological syndromes. The current study assessed DLM mediated oxidative stress, behavioral, hematological, histopathological, and biochemical toxic effects on silver carp (Hypophthalmichthys molitrix). Exposure to an acute concentration (2 mu/L) of DLM resulted in different behavioral inconsistencies and a time-dependent significant (P 0.05) change in the hematology and serum biochemistry of silver carp. A significant (P 0.05) increase in the activities of reactive oxygen species, lipid peroxidation, and antioxidant enzymes whereas a significant decrease in total protein contents in the liver, gills, brain, and muscle tissues were observed. DLM exposure increased the activities of metabolic enzymes in the gills, muscles, and liver of silver carp. A significant (P 0.05) increase in DNA damage in peripheral blood erythrocytes was evident. DLM exposure led to a time-dependent significant (P 0.05) increase in the whole-body cortisol and blood glucose level, while a significant decrease in acetylcholine esterase activity in the brain, liver, and muscle tissues. Different histopathological changes in the liver, gills, brain, and intestine were observed, however, no significant change in the gross anatomy and morphometric parameters of the fish was observed. The current study provides valuable information for devising better strategies regarding environmental management, chemicals' risk assessment, biodiversity conservation, and monitoring of the aquatic organisms. DLM was concluded to be highly toxic to fish. The extensive use of DLM should be prohibited or allowed under strict environmental laws; otherwise, it might lead to the extermination of the susceptible wildlife, such as commercially very valuable but nearly threatened silver carp. (C) 2018 Elsevier Ltd. All rights reserved.
机译：溴氰菊酯（DLM）是α-氰基（II型）合成拟除虫菊酯。暴露于DLM会导致强烈的神经毒性作用和许多复杂的毒理学综合症。当前的研究评估了DLM介导的氧化应激，行为，血液学，组织病理学和生化毒性对silver鱼的影响（Hypophthalmichthys molitrix）。急性浓度（2 mu / L）的DLM暴露导致silver鱼血液学和血清生化方面的行为不一致和时间依赖性显着（P <0.05）变化。活性氧，脂质过氧化和抗氧化酶的活性显着增加（P <0.05），而肝脏，腮，大脑和肌肉组织中的总蛋白质含量则显着降低。暴露于DLM会增加silver鱼the，肌肉和肝脏中代谢酶的活性。外周血红细胞DNA损伤明显增加（P <0.05）。 DLM暴露导致全身皮质醇和血糖水平随时间显着增加（P <0.05），而脑，肝和肌肉组织中乙酰胆碱酯酶活性则显着下降。在肝脏，腮，脑和肠中观察到不同的组织病理学变化，但是，未观察到鱼的总体解剖学和形态参数显着变化。当前的研究提供了宝贵的信息，可用于制定有关环境管理，化学品风险评估，生物多样性保护和水生生物监测的更好策略。结论是DLM对鱼类有剧毒。严格的环境法律应禁止或允许DLM的广泛使用；否则，它可能导致易感野生生物灭绝，例如商业上非常有价值但濒临绝种的silver鱼。 （C）2018 Elsevier Ltd.保留所有权利。

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