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首页> 外文期刊>Chemosphere >Comparative study on the migration of di-2-ethylhexyl phthalate (DEHP) and tri-2-ethylhexyl trimellitate (TOTM) into blood from PVC tubing material of a heart-lung machine
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Comparative study on the migration of di-2-ethylhexyl phthalate (DEHP) and tri-2-ethylhexyl trimellitate (TOTM) into blood from PVC tubing material of a heart-lung machine

机译：邻苯二甲酸二-2-乙基己基苯二酸酯（DEHP）和偏苯三酸三-2-乙基己基酯（TOTM）从心肺机PVC管材料中迁移到血液中的比较研究

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摘要

Medical devices like blood tubing often consist of PVC material that requires the addition of plasticizers. These plasticizers may migrate into the blood leading to an exposure of the patients. In this study the migration behavior of three different blood tubing sets (PVC material with two different plasticizers and silicone as control material) applied on a heart-lung machine standardly used for cardiopulmonary bypass (CPB) in children was studied. We analyzed the total plasticizer migration by analysis of both, the parent compounds as well as their primary degradation products in blood. Additionally, the total mass loss of the tubing over perfusion time was examined. The PVC tubing plasticized with DEHP (di-2-ethylhexyl phthalate) was found to have the highest mass loss over time and showed a high plasticizer migration rate. In comparison, the migration of TOTM (tri-2-ethylhexyl trimellitate) and its primary degradation products was found to be distinctly lower (by a factor of approx. 350). Moreover, it was observed that the storage time of the tubing affects the plasticizer migration rates. In conclusion, the DEHP substitute TOTM promises to be an effective alternative plasticizer for PVC medical devices particularly regarding the decreased migration rate during medical procedures. (C) 2015 Elsevier Ltd. All rights reserved.
机译：诸如血液管之类的医疗设备通常由需要添加增塑剂的PVC材料组成。这些增塑剂可能迁移到血液中，导致患者暴露。在这项研究中，研究了三种不同的血液管道（带有两种不同的增塑剂的PVC材料和有机硅作为对照材料）在儿童肺活体外（CPB）标准心肺机上的迁移行为。我们通过分析母体化合物及其在血液中的主要降解产物来分析总增塑剂的迁移。另外，检查了在灌注时间内管道的总质量损失。发现用DEHP（邻苯二甲酸二-2-乙基己基酯）塑化的PVC管在一段时间内质量损失最高，并显示出较高的增塑剂迁移率。相比之下，发现TOTM（偏苯三酸三-2-乙基己基酯）及其主要降解产物的迁移明显较低（降低了约350倍）。此外，已观察到管的储存时间影响增塑剂的迁移速率。总之，DEHP替代品TOTM有望成为PVC医疗器械的有效替代增塑剂，尤其是在医疗程序中迁移率降低方面。 （C）2015 Elsevier Ltd.保留所有权利。

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  • 来源
    《Chemosphere》 |2016年第2期|10-16|共7页
  • 作者

    Eckert Elisabeth; Muench Frank; Goeen Thomas; Purbojo Ariawan; Mueller Johannes; Cesnjevar Robert;

  • 作者单位

    Univ Erlangen Nurnberg, Inst & Outpatient Clin Occupat Social & Environm, Schillerstr 25-29, D-91054 Erlangen, Germany;

    Univ Hosp Erlangen, Dept Pediat Cardiac Surg, Loschgestr 15, D-91054 Erlangen, Germany;

    Univ Erlangen Nurnberg, Inst & Outpatient Clin Occupat Social & Environm, Schillerstr 25-29, D-91054 Erlangen, Germany;

    Univ Hosp Erlangen, Dept Pediat Cardiac Surg, Loschgestr 15, D-91054 Erlangen, Germany;

    Univ Erlangen Nurnberg, Inst & Outpatient Clin Occupat Social & Environm, Schillerstr 25-29, D-91054 Erlangen, Germany;

    Univ Hosp Erlangen, Dept Pediat Cardiac Surg, Loschgestr 15, D-91054 Erlangen, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Plasticizers; Blood tubing; Silicone; Medical devices; PVC; Leaching;

    机译：增塑剂;输油管;硅树脂;医疗器械;PVC;浸出;

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