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首页> 外文期刊>Chemosphere >Oxidative stress and arsenic toxicity: Role of NADPH oxidases
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Oxidative stress and arsenic toxicity: Role of NADPH oxidases

机译：氧化应激和砷毒性：NADPH氧化酶的作用

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摘要

The effect of arsenic (25 and 50 μM As for 1 and 5 d) was analysed in wild type (WT) and Arabidopsis tha-liana (L.) Heynh plants deficient in NADPH oxidase C (AtrbohC). The content of H_2O_2 and malondialdehyde (MDA) increased with the As concentration, while the opposite effect was found for NO in WT and AtrbohC plants. The As treatment reduced catalase and increased glutathione reductase activities to the same extent in WT and AtrbohC plants, although the induction of all SOD isoforms (mainly CuZn-SODs) was observed in WT plants, the opposite effects being found in AtrbohC plants. Glycolate oxidase (H_2O_2 producers) considerably increased with the concentration and time of treatment with As in WT and AtrbohC mutants. Arsenic induced the uptake and translocation of P, S, Cu, Zn, and Fe in WT plants, while in AtrbohC plants the opposite trend was noted and the uptake of As became considerably lower than in WT plants. These results suggest that As causes oxidative stress by inducing glycolate oxidase, while NADPH oxidase does not appear to participate in ROS overproduction but could be critical in regulating antiox-idant defences as well as the transport and translocation of As and macro/micronutrients.
机译：在缺乏NADPH氧化酶C（AtrbohC）的野生型（WT）和拟南芥tha-liana（L.）Heynh植物中分析了砷的影响（分别为25和50μM，分别为1和5 d）。 H_2O_2和丙二醛（MDA）的含量随As浓度的增加而增加，而野生型和AtrbohC型植物中NO的作用相反。尽管在WT植物中观察到所有SOD同工型（主要是CuZn-SODs）的诱导，但As处理在WT和AtrbohC植物中以相同程度降低了过氧化氢酶并增加了谷胱甘肽还原酶活性，而在AtrbohC植物中发现了相反的作用。 WT和AtrbohC突变体中，乙醇酸氧化酶（H_2O_2的产生者）随着As浓度和处理时间的增加而大大增加。砷诱导了WT植物中P，S，Cu，Zn和Fe的吸收和转运，而在AtrbohC植物中则注意到了相反的趋势，并且砷的吸收明显低于WT植物。这些结果表明，As通过诱导乙醇酸氧化酶而引起氧化应激，而NADPH氧化酶似乎不参与ROS的过量生产，但在调节抗氧剂防御以及As和宏/微量营养素的运输和转运中可能至关重要。

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  • 来源
    《Chemosphere》 |2013年第6期|1987-1996|共10页
  • 作者

    D.K. Gupta; M. Inouhe; M. Rodriguez-Serrano; M.C. Romero-Puertas; L.M. Sandalio;

  • 作者单位

    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSJC, C/Prof. Albareda 1, Granada E-18008, Spain;

    Department of Biology, Faculty of Science, Ehime University, Matsuyama 790-8577, Japan;

    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSJC, C/Prof. Albareda 1, Granada E-18008, Spain;

    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSJC, C/Prof. Albareda 1, Granada E-18008, Spain;

    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSJC, C/Prof. Albareda 1, Granada E-18008, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antioxidants; arabidopsis; arsenic; NADPH oxidase; reactive oxygen species (ROS); nutrients;

    机译：抗氧化剂;拟南芥;砷;NADPH氧化酶;活性氧（ROS）;营养素;

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