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首页> 外文期刊>Chemosphere >Determination of oral uptake and biodistribution of platinum and chromium by the garden snail (Helix aspersa) employing nano-secondary ion mass-spectrometry
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Determination of oral uptake and biodistribution of platinum and chromium by the garden snail (Helix aspersa) employing nano-secondary ion mass-spectrometry

机译：庭园蜗牛（Helix aspersa）采用纳米二次离子质谱法测定口服吸收和铂和铬的生物分布

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摘要

Environmental heavy metal contamination is a case of concern for both animal and human health. Studying the fate of metals in plant or animal tissues may provide information on pollution. In the present study, we investigated the possibility to follow the biological fate of chromium and platinum uptake in common garden snails (Helix aspersa), typically accumulating high concentrations of metals from their environment. Chromium and platinum were administered orally to snails in 5 groups (n - 25/group): control, food contaminated by ca. 2.5 μg g~(-1) and 19 μg g~(-1) chromium and 2.5 μg g~(-1) and 25 μg g~(-1) platinum, for 8 weeks. Following exposure, surviving snails were sacrificed, shell and remaining tissue investigated by ICP-MS, and shell, midgut gland and mantle by nano-secondary ion mass-spectrometry (Nano-SIMS). ~(12)C~(14)N-normalized platinum and ~(40)Ca-normalized chromium measurements indicated highest enrichments in cellular vesicles of the midgut gland, and lower concentrations in mantle and shell, with significantly higher platinum and chromium concentrations in the 2 exposure groups vs. control (P< 0.05), with somewhat differing distribution patterns for chromium and platinum. Comparable results were obtained by ICP-MS, with both chromium and platinum fed snails showing drastically elevated concentrations of metals in shell (up to 78 and 122 μg g~(-1) dw platinum and chromium, respectively) and in other tissues (up to 200 and 1125 μg g~(-1) dw platinum and chromium, respectively). Nano-SIMS allowed for semi-quantitative comparison of metal fate in snail tissues, making this an interesting technique for future studies in the area of environmental pollution.
机译：环境重金属污染是动物和人类健康都需要关注的一个案例。研究植物或动物组织中金属的命运可能提供有关污染的信息。在本研究中，我们调查了常见的庭园蜗牛（Helix aspersa）吸收铬和铂的生物命运的可能性，通常蜗牛会从其环境中积累高浓度的金属。将铬和铂经口给药于蜗牛，共5组（n-25 /组）：对照组，被ca污染的食物。 2.5克g〜（-1）和19克g〜（-1）铬和2.5克g〜（-1）和25克g〜（-1）铂，连续8周。暴露后，处死存活的蜗牛，通过ICP-MS研究壳和剩余组织，并通过纳米二次离子质谱法（Nano-SIMS）研究壳，中肠腺和地幔。 〜（12）C〜（14）N归一化的铂和〜（40）Ca归一化的铬测量表明，中肠腺的细胞囊泡中富集度最高，而地幔和壳中的浓度较低，而中肠中铂和铬的浓度显着较高。 2个暴露组与对照组相比（P <0.05），铬和铂的分布方式略有不同。通过ICP-MS获得了可比的结果，铬和铂喂养的蜗牛都显示出壳中（分别高达78和122μgg〜（-1）dw铂和铬，分别高达78和122μgg〜（-1）dw的金属）和其他组织（向上分别达到200和1125μgg〜（-1）dw的铂和铬。纳米SIMS可以对蜗牛组织中的金属命运进行半定量比较，这使其成为将来在环境污染领域研究的有趣技术。

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  • 来源
    《Chemosphere》 |2013年第6期|1829-1838|共10页
  • 作者

    Tanja Eybe; Jean-Nicolas Audinot; Thomas Udelhoven; Esther Lentzen; Brahime El Adib; Johanna Ziebel; Lucien Hoffmann; Torsten Bohn;

  • 作者单位

    Centre de Recherche Public-Gabriel Lippmann, Environment and Agro-biotechnologies Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Material Sciences Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Environment and Agro-biotechnologies Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Material Sciences Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Material Sciences Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Environment and Agro-biotechnologies Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Environment and Agro-biotechnologies Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

    Centre de Recherche Public-Gabriel Lippmann, Environment and Agro-biotechnologies Department, 41 Rue du Brill, L-4422 Belvaux, Luxembourg;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    snails; chromium; platinum; Nano-SIMS; ICP-MS; oral uptake;

    机译：蜗牛;铬;铂;纳米SIMS;ICP-MS;口服吸收;

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