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首页> 外文期刊>Chemosphere >Determination of selected perfluorinated compounds and polyfluoroalkyl phosphate surfactants in human milk
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Determination of selected perfluorinated compounds and polyfluoroalkyl phosphate surfactants in human milk

机译：母乳中选定全氟化合物和多氟烷基磷酸酯表面活性剂的测定

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Polyfluoroalkyl phosphate surfactants (PAPS) are used on food contact paper to impart oil/grease resistance and have been shown to be able to migrate into food. The biotransformation of the congeners belonging to this class of compounds is considered to be a potential source of perfluorinated carboxylic acids (PFCAs). In this study, two methods were developed for the determination of seven perfluorinated compounds (PFCs) and eight polyfluorinated disubstituted phosphate surfactants (diPAPS) in human milk. PFCs were extracted from milk using an ion-pairing technique; while the diPAPs extraction involved a sample clean up using solid phase extraction. Analyses of all compounds in this study were performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Of the seven PFCs analyzed in human milk, only perfluorooctanoic acid (PFOA) was detected in eleven out of thirteen (85%) individual human milk samples analyzed, with a concentration range of <0.072 to 0.52 ng mL~(-1) Four diPAPS were detected and quantified in human milk samples. Eight out of thirteen samples contained 4:2 diPAP with a concentration range of <0.01-0.26 ng mL~(-1); 6:2 diPAP was detected in five samples with a concentration range of <0.01-0.14 ng mL~(-1); 8:2 diPAP was detected in only three samples with concentrations of 0.21, 0.27, and 0.30 ng mL~(-1). The 10:2 diPAP was quantified in seven milk samples, with concentration range of <0.01-0.83 ng mL~(-1). No correlation was established between PFCAs and PAPS levels in this small sample size. To the best of the authors' knowledge, this is the first study to report the presence of PAPS in human milk.
机译：食品接触纸上使用了聚氟烷基磷酸酯表面活性剂（PAPS），以赋予耐油/油脂性，并且已证明能够迁移到食品中。属于此类化合物的同类物的生物转化被认为是全氟化羧酸（PFCA）的潜在来源。在这项研究中，开发了两种方法来测定母乳中的七种全氟化合物（PFC）和八种多氟二取代磷酸盐表面活性剂（diPAPS）。使用离子对技术从牛奶中提取PFC；而diPAPs提取涉及使用固相提取进行样品净化。本研究中所有化合物的分析均通过液相色谱-串联质谱（LC-MS / MS）进行。在母乳中分析的7种PFC中，在分析的13种个人乳样品中，有11种（85％）仅检测到全氟辛酸（PFOA），浓度范围为<0.072至0.52 ng mL〜（-1）四种diPAPS在人乳样品中进行了检测和定量。 13个样本中有8个包含4：2 diPAP，浓度范围<0.01-0.26 ng mL〜（-1）；在五个样品中检测到6：2 diPAP，浓度范围<0.01-0.14 ng mL〜（-1）；仅在三个浓度分别为0.21、0.27和0.30 ng mL〜（-1）的样品中检测到8：2 diPAP。在七个牛奶样品中定量10：2 diPAP，浓度范围<0.01-0.83 ng mL〜（-1）。在这个小样本中，PFCA和PAPS水平之间没有建立相关性。据作者所知，这是第一项报道母乳中存在PAPS的研究。

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