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首页> 外文期刊>Chemosphere >Neurobehavioral effects, c-Fos/Jun expression and tissue distribution in rat offspring prenatally co-exposed to MeHg and PFOA: PFOA impairs Hg retention
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Neurobehavioral effects, c-Fos/Jun expression and tissue distribution in rat offspring prenatally co-exposed to MeHg and PFOA: PFOA impairs Hg retention

机译：神经行为效应，c-Fos / Jun表达和产后与MeHg和PFOA共同暴露的大鼠后代中的组织分布：PFOA损害了Hg的保留

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摘要

Exposure to methylmercury (MeHg) and perfluorooctanoic acid (PFOA) can occur simultaneously as both contaminants are found in the same food sources, especially fish, seafood, marine mammals and milk. The aim of this study was to assess the effects of exposure to MeHg (10 μg mL~(-1) in drinking water) and PFOA (10 μg mL~(-1) in drinking water) from gestational day 1 to postnatal day (PND) 21, alone and in combination, on neurobehavioral development and the expression of c-Fos/Jun in different brain regions in the offspring. Our findings showed that exposure to MeHg alone, and exposure to MeHg combined with PFOA significantly induced cliff avoidance reflexes and negative geotaxis reflexes. And these effects appeared to be greater following exposure to MeHg alone. MeHg and/or PFOA exposure did not significantly impair motor coordination functions, or cause significant changes in c-Fos expression in the hippocampus and cerebellum, and spatial learning tests were similar to those in the controls, thus it was impossible to determine whether combined exposure to MeHg and PFOA had any additional effects on both hippocampus and cerebellum regions. However, a significant increase in the frequency of line crossing was observed in rats treated with MeHg or PFOA alone, and there were no significant differences between the MeHg + PFOA-treated group and the controls, suggesting that PFOA was antagonistic to MeHg toxicity in the locomotor activity test. Co-exposure to MeHg and PFOA decreased all tissue Hg concentrations in pups compared to the group exposed to MeHg only, suggesting that PFOA impaired Hg retention in different tissues.
机译：甲基汞（MeHg）和全氟辛酸（PFOA）可能同时暴露，因为两种污染物都存在于相同的食物来源中，尤其是鱼类，海鲜，海洋哺乳动物和牛奶。这项研究的目的是评估从妊娠第1天到产后第1天（暴露于饮用水中的MeHg（10μgmL〜（-1））和PFOA（饮用水中的10μgmL〜（-1））的影响（ （PND）21，单独或组合使用，涉及后代不同大脑区域的神经行为发育和c-Fos / Jun的表达。我们的研究结果表明，单独暴露于MeHg，以及暴露于MeHg与PFOA联合均可显着诱发避壁反射和负地轴反射。而仅暴露于甲基汞后，这些影响似乎更大。 MeHg和/或PFOA暴露不会明显损害运动协调功能，也不会引起海马和小脑c-Fos表达的显着变化，并且空间学习测试与对照组相似，因此无法确定是否合并暴露MeHg和PFOA的剂量对海马和小脑区域都具有任何其他作用。但是，在单独用MeHg或PFOA治疗的大鼠中观察到线交的频率显着增加，并且在MeHg + PFOA治疗的组与对照组之间没有显着差异，这表明PFOA可以拮抗MeHg毒性。运动活动测试。与仅暴露于MeHg的组相比，共同暴露于MeHg和PFOA会降低幼崽中所有组织Hg的浓度，这表明PFOA会损害不同组织中Hg的保留。

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  • 来源
    《Chemosphere》 |2013年第6期|758-764|共7页
  • 作者

    Jinping Cheng; Masatake Fujimura; Wenchang Zhao; Wenhua Wang;

  • 作者单位

    School of Environmental Science and Engineering. Shanghai Jiao Tong University, Shanghai 200240, China;

    Department of Basic Medical Sciences, National Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan;

    School of Environmental and Safety Engineering, Changzhou University, Changzhou, Jiangsu 213164, China;

    School of Environmental Science and Engineering. Shanghai Jiao Tong University, Shanghai 200240, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    methylmercury; perfluorooctanoic acid; c-Fos/Jun expression; locomotor activity test;

    机译：甲基汞全氟辛酸c-Fos / Jun表达式;运动活动测试;

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