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首页> 外文期刊>Chemosphere >Calorimetric evaluation of interaction and absorption of polychlorinated biphenyls by biomembrane models
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Calorimetric evaluation of interaction and absorption of polychlorinated biphenyls by biomembrane models

机译：用生物膜模型量热评估多氯联苯的相互作用和吸收

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摘要

Polychlorinated biphenyls (PCBs) are organic pollutants with lipophilic properties, due to their persistence, they are present in environment at potentially dangerous concentrations for humans health. In this work we investigated the interaction and absorption of 2,4,4'-trichlorobiphenyl (PCB 28), 2,3,3',4,4'-pentachlo-robiphenyl (PCB 105) and 2,3,3',4,4',5,5'-eptachlorobiphenyl (PCB 189) with dimyristoylphosphatidylcho-line (DMPC) multilamellar vesicles (MLV), chosen as biomembrane models, by differential scanning calorimetry technique (DSC). The obtained results indicate that the tested compounds affected the thermotropic behaviour of MLV to different degree, modifying the phase transition peak and shifting it towards lower temperature. The effect of an aqueous or lipophilic medium on the absorption process of these compounds by the biomembrane models was also investigated revealing that the process is hindered by the aqueous medium but favoured by the lipophilic medium.
机译：多氯联苯（PCBs）是具有亲脂性的有机污染物，由于其持久性，它们以对人体健康有害的潜在浓度存在于环境中。在这项工作中，我们研究了2,4,4'-三氯联苯（PCB 28），2,3,3'，4,4'-五溴联苯（PCB 105）和2,3,3'的相互作用和吸收，通过差示扫描量热技术（DSC）将4,4'，5,5'-七氯联苯（PCB 189）与二肉豆蔻酰基磷脂酰胆碱（DMPC）多层囊泡（MLV）选作生物膜模型。获得的结果表明，所测试的化合物在不同程度上影响了MLV的热致行为，改变了相变峰并将其移向较低温度。还研究了水性或亲脂性介质对生物膜模型吸收这些化合物的过程的影响，揭示了该过程受水性介质的阻碍，但受亲脂性介质的促进。

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  • 来源
    《Chemosphere》 |2013年第6期|791-796|共6页
  • 作者

    Vito Librando; Zelica Minniti; Maria Lorena Accolla; Orazio Cascioc; Francesco Castelli; Maria Grazia Sarpietro;

  • 作者单位

    Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A Doria 6, 95125 Catania, Italy;

    Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A Doria 6, 95125 Catania, Italy;

    Dipartimento di Scienze delta Salute, Universita 'Magna Græcia' di Catanzaro, Viale S. Venuta, 88100 Cermaneto (CZ), Italy;

    Dipartimento 'C. F. Ingrassia' Universita degli Studi di Catania, Via S. Sofia 87, 95123 Catania, Italy;

    Dipartimento di Scienze del Farmaco, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy;

    Dipartimento di Scienze del Farmaco, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    polychlorinated biphenyls; differential scanning calorimetry; biomembrane model; dimyristoylphosphatidylcholine;

    机译：多氯联苯;差示扫描量热法;生物膜模型二肉豆蔻酰基磷脂酰胆碱;

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