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首页> 外文期刊>Chemosphere >Occurrence of perfluorinated alkylated substances in breast milk of French women and relation with socio-demographical and clinical parameters: Results of the ELFE pilot study
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Occurrence of perfluorinated alkylated substances in breast milk of French women and relation with socio-demographical and clinical parameters: Results of the ELFE pilot study

机译：法国女性母乳中全氟烷基化物质的发生及其与社会人口统计学和临床​​参数的关系：ELFE初步研究的结果

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摘要

A previously developed and validated methodology based on liquid chromatography coupled to high resolution mass spectrometry was used for determine the concentration levels of 14 perfluoroalkylated substances (PFASs) in a set of 48 breast milk samples collected from French women in the frame of the ELFE pilot study. In accordance with other similar studies conducted at european and international levels, PFOS, PFOA, and PFHxS were detected and quantified in most of the analyzed samples (90%, 98% and 100%, respectively), and appeared as major contributors to the total PFAS exposure (38%, 37%, 25%, respectively), whereas the other targeted PFAS were very rarely, if not, found at the limits of detection of the method. Also in agreement with other published data, the concentration levels measured for the detected substances varied from <0.05 to 0.33 μg/L for PFOS (median = 0.079), from <0.05 to 0.22 μg/L for PFOA (median = 0.075), and from 0.04 to 0.07 μg/L for PFHxS (median = 0.050). On the basis of this relatively limited data set, no statistically significant relation was observed between these exposure levels and developmental outcomes, in particular the weight at birth. Similarly, no relation was observed between the measured PFAS levels and various socio-demographical parameters including the consumption of seafood, alcohol, smoking, or socio-economical level. These results suggest a need for further research and better knowledge regarding the sources, pharmacokinetics, and factors of exposure for other substances belonging to this class of emerging contaminants.
机译：在ELFE试点研究的框架内，采用了基于液相色谱和高分辨率质谱联用的先前开发和验证的方法，用于确定48份母乳样品中14种全氟烷基化物质（PFAS）的浓度水平。 。根据在欧洲和国际上进行的其他类似研究，在大多数分析样品（分别为90％，98％和100％）中检测和定量了PFOS，PFOA和PFHxS，并在总含量中起了主要作用。 PFAS暴露（分别为38％，37％，25％），而其他针对性的PFAS（如果没有的话）则很少出现在该方法的检测极限范围内。同样与其他已发布的数据一致，对于全氟辛烷磺酸，检测到的物质的浓度水平从<0.05至0.33μg/ L变化（中位数= 0.079），对于全氟辛烷磺酸从<0.05至0.22μg/ L（中位数= 0.075），并且PFHxS为0.04至0.07μg/ L（中位数= 0.050）。基于这一相对有限的数据集，这些暴露水平与发育结果（尤其是出生时的体重）之间没有观察到统计学上的显着关系。同样，在测得的PFAS水平与各种社会人口统计学参数（包括海鲜消费，饮酒，吸烟或社会经济水平）之间也没有发现任何关系。这些结果表明，需要对属于此类新兴污染物的其他物质的来源，药代动力学和暴露因素进行进一步的研究和了解。

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  • 来源
    《Chemosphere》 |2013年第6期|802-808|共7页
  • 作者

    Jean-Philippe Antignac; Bruno Veyrand; Hanane Kadar; Philippe Marchand; Amivi Oleko; Bruno Le Bizec; Stephanie Vandentorren;

  • 作者单位

    LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Risidus et Contaminants dans les Aliments (LABERCA), Nantes, France ,Institut National de la Recherche Agronomique, INRA, Centre de recherche Angers-Nantes, Site de la Ceraudiere, Nantes, France;

    LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Risidus et Contaminants dans les Aliments (LABERCA), Nantes, France;

    LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Risidus et Contaminants dans les Aliments (LABERCA), Nantes, France;

    LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Risidus et Contaminants dans les Aliments (LABERCA), Nantes, France;

    Institut de Veille Sanitaire (InVS), Saint-Maurice, France;

    LUNAM Universite, Oniris, USC 1329 Laboratoire d'Etude des Risidus et Contaminants dans les Aliments (LABERCA), Nantes, France;

    Institut de Veille Sanitaire (InVS), Saint-Maurice, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    perfluorinated alkylated substances; breast milk; perinatal exposure; endocrine disruption;

    机译：全氟烷基化物质;母乳围产期暴露;内分泌干​​扰;

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