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The association between maternal nonylphenol exposure and parity on neonatal birth weight: A cohort study in Taiwan

机译:孕妇壬基酚暴露与胎龄与新生儿出生体重之间的关系:台湾一项队列研究

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摘要

Background: The aim of this study was to explore the association between NP exposure and parity and their effect on neonatal birth weight. Methods: A cohort of pregnant women was established in a medical center in North Taiwan. Urinary NP concentration was determined by high-performance liquid chromatography coupled with fluorescent detection and adjusted using creatinine. A multivariable regression model was fit to determine the association between the maternal NP level in each trimester and neonatal birth weight. The odds ratios (ORs) of infant birth weight below the 10th, 25th, and 50th percentiles, comparing pregnant women with the different NP exposure levels, was estimated using a logistic regression. Results: Of the 162 pregnant women in the study, 99 were multiparas and 63 were primiparas. After adjusting for other covariates, the NP level in the second trimester had a significant association with birth weight in the primiparas (β = -182.49 g, p value - 0.02). The OR of low infant birth weight, comparing pregnant women with different NP levels, was increased by decreasing the cutoff percentile for birth weight (OR= 1.18 for the 50th percentile, 2.12 for the 25th percentile, and 7.81 for the 10th percentile). The odds of primiparas with high NP level having a low neonatal birth weight increased to 3.87, 11.77, and 9.40 for the three different percentiles (p value < 0.05). Conclusion: Maternal NP exposure level is associated with an increased risk of low neonatal weight. Primiparas are especially at risk, and the second trimester of pregnancy may be the critical stage of exposure.
机译:背景:这项研究的目的是探讨NP暴露和胎次及其对新生儿出生体重的影响之间的关联。方法:在台湾北部的医疗中心建立了一组孕妇。通过高效液相色谱结合荧光检测确定尿中NP浓度,并使用肌酐进行调整。拟合多元回归模型来确定每个孕期孕妇的NP水平与新生儿出生体重之间的关系。使用logistic回归估计法比较了具有不同NP暴露水平的孕妇,婴儿出生体重低于10、25和50%的比值比(OR)。结果:在该研究的162名孕妇中,多胎孕妇99例,初产妇63例。调整其他协变量后,孕中期的NP水平与初产妇的出生体重显着相关(β= -182.49 g,p值-0.02)。通过降低出生体重的临界百分位数,可以增加低出生体重婴儿的OR值(降低第50个百分位数的OR阈值百分数,第25个百分位数的2.12和第10个百分位数7.81)。对于三个不同的百分位数,新生儿出生体重较低的NP水平较高的初产妇的几率分别提高至3.87、11.77和9.40(p值<0.05)。结论:孕妇NP暴露水平与低体重新生儿的风险增加有关。初产妇尤其处于危险之中,妊娠中期可能是暴露的关键阶段。

著录项

  • 来源
    《Chemosphere》 |2013年第6期|1145-1152|共8页
  • 作者单位

    Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan;

    Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan;

    Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan;

    Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan;

    School of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan;

    Department of Obstetrics and Cynecology, Chang Cung Memorial Hospital, Taoyuan, Taiwan;

    Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan;

    Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan;

    Department of OBS & CYN, Cathay General Hospital, Taipei, Taiwan,School of Medicine, Fu Jen Catholic University, Taipei, Taiwan,School of Medicine, Taipei Medical University, Taipei, Taiwan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Birth weight; Nonylphenol; Pregnant woman; Primipara;

    机译:出生体重;壬基酚怀孕的女人;初产妇;

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