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首页> 外文期刊>Chemosphere >Toxicity of TiO_2, ZrO_2, Fe~0, Fe_2O_3, and Mn_2O_3 nanoparticles to the yeast, Saccharomyces cerevisiae
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Toxicity of TiO_2, ZrO_2, Fe~0, Fe_2O_3, and Mn_2O_3 nanoparticles to the yeast, Saccharomyces cerevisiae

机译：TiO_2，ZrO_2，Fe〜0，Fe_2O_3和Mn_2O_3纳米颗粒对酵母菌的毒性

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摘要

The growing application of engineered nanomaterials is leading to an increased occurrence of nanoparticles (NPs) in the environment. Thus, there is a need to better understand their potential impact on the environment. This study evaluated the toxicity of nanosized TiO_2, ZrO_2, Fe~0, Fe_2O_3, and Mn_2O_3 towards the yeast Saccharomyces cerevisiae based on O_2 consumption and cell membrane integrity. In addition, the state of dispersion of the nanoparticles in the bioassay medium was characterized. All the nanomaterials showed high tendency to aggregate in the bioassay medium. A non-toxic poly-acrylate dispersant was used to improve the NP dispersion stability and test the influence of the aggregation state in their toxicity. Mn_2O_3 NPs showed the highest inhibition of O_2 consumption (50% at 170 mg L~(-1)) and cell membrane damage (approximately 30% of cells with compromised membrane at 1000 mg L~(-1)), while the other NPs caused low (Fe~0) or no toxicity (TiO_2, ZrO_2, and Fe_2O_3) to the yeast. Dispersant supplementation decreased the inhibition caused by Mn_2O_3 NPs at low concentrations, which could indicate that dispersant association with the particles may have an impact on the interaction between the NPs and the cells.
机译：工程纳米材料的日益增长的应用导致环境中纳米颗粒（NPs）的出现增加。因此，需要更好地了解它们对环境的潜在影响。本研究基于O_2的消耗和细胞膜的完整性，评价了纳米TiO_2，ZrO_2，Fe〜0，Fe_2O_3和Mn_2O_3对酿酒酵母的毒性。另外，表征了纳米颗粒在生物测定介质中的分散状态。所有的纳米材料都显示出在生物测定介质中高度聚集的趋势。使用无毒的聚丙烯酸酯分散剂可改善NP分散稳定性，并测试聚集状态对其毒性的影响。 Mn_2O_3 NPs对O_2消耗的抑制作用最大（在170 mg L〜（-1）时为50％）和细胞膜损伤（在1000 mg L〜（-1）时约有30％的细胞膜受损），而其他NPs对酵母造成的毒性低（Fe〜0）或无毒性（TiO_2，ZrO_2和Fe_2O_3）。分散剂的添加降低了低浓度下Mn_2O_3 NPs引起的抑制作用，这可能表明分散剂与颗粒的缔合可能会影响NPs与细胞之间的相互作用。

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  • 来源
    《Chemosphere》 |2013年第6期|1201-1206|共6页
  • 作者

    Lila Otero-Gonzalez; Citlali Garcia-Saucedo; James A. Field; Reyes Sierra-Alvarez;

  • 作者单位

    Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ, USA;

    Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ, USA;

    Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ, USA;

    Department of Chemical and Environmental Engineering, University of Arizona, P.O. Box 210011, Tucson, AZ, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Titanium oxide; Zero-valent iron; Manganese oxide; Inorganic nanoparticles; Cytotoxicity; Nanotoxicology;

    机译：钛氧化物零价铁;氧化锰无机纳米粒子;细胞毒性;纳米毒理学;

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