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首页> 外文期刊>Chemosphere >Inflammatory stress response in A549 cells as a result of exposure to coal: Evidence for the role of pyrite in coal workers' pneumoconiosis pathogenesis
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Inflammatory stress response in A549 cells as a result of exposure to coal: Evidence for the role of pyrite in coal workers' pneumoconiosis pathogenesis

机译：暴露于煤炭导致A549细胞的炎症应激反应：黄铁矿在煤矿工人尘肺病发病机理中的作用的证据

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摘要

On the basis of a recent epidemiological study it is hypothesized that pyrite content in coal is an important factor in coal workers' pneumoconiosis (CWP) pathogenesis. While the role of pyrite in pathogenesis remains to be resolved, the ability of the mineral to generate reactive oxygen species (ROS) through various mechanisms is likely a contributing factor. The aim of this study was to elucidate the importance of the pyrite content of coat in generating an inflammatory stress response (ISR), which is defined as the upregulation of ROS normalized by cell viability. The ISR of A549 human lung epithelial cells in the presence of natural coal samples with variable pyrite contents was measured. Normalized to surface area, five particle loadings for each coal reference standard were analyzed systematically for a total of 24 h. The ISR generated by coals containing 0.00, 0.01, and 0.49 wt.% pyritic sulfur is comparable to, though less than, the ISR generated by inert glass beads (299% of the control). The coals containing 0.52 and 1.15 wt.% pyritic sulfur generated the greatest ISR (798% and 1426% of the control, respectively). Conclusions: While ISR does not increase proportionally to pyrite content in coal, the two coals with the highest pyritic sulfur and available iron contents generate the greatest ISR. Therefore, the present study indicates that coals with elevated pyrite contents are likely to induce a significant health burden by stimulating inflammation within the lungs, and may contribute to the development of CWP.
机译：根据最近的一项流行病学研究，假设煤中的黄铁矿含量是煤矿工人尘肺病（CWP）发病机理的重要因素。尽管黄铁矿在发病机理中的作用尚待解决，但矿物通过各种机制产生活性氧（ROS）的能力可能是一个促成因素。这项研究的目的是阐明外皮中黄铁矿含量在产生炎症应激反应（ISR）中的重要性，该反应被定义为通过细胞生存力正常化的ROS上调。在存在可变黄铁矿含量的天然煤样品中，测量了A549人肺上皮细胞的ISR。归一化为表面积，系统分析了每种煤参考标准品的五个颗粒负载量，共计24小时。含有0.00、0.01和0.49 wt。％的硫铁矿的煤所产生的ISR与惰性玻璃珠所产生的ISR相当（尽管是对照的299％），但与之相当。含有0.52和1.15 wt。％黄铁矿硫的煤产生最大的ISR（分别为对照的798％和1426％）。结论：尽管ISR与煤中黄铁矿含量不成比例增加，但黄铁矿硫和有效铁含量最高的两种煤却产生了最大的ISR。因此，本研究表明，硫铁矿含量较高的煤可能会通过刺激肺部的炎症而引起巨大的健康负担，并可能促进CWP的发展。

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  • 来源
    《Chemosphere》 |2013年第6期|1216-1221|共6页
  • 作者

    Andrea D. Harrington; Stella E. Tsirka; Martin A.A. Schoonen;

  • 作者单位

    Department of Geosciences, Earth and Space Sciences Building, Stony Brook University, Stony Brook, NY 11784-2100, USA,Institute of Environmental Medicine, New York University, 57 Old Forge Road, Tuxedo, NY 10987, USA;

    Pharmacological Sciences - Stony Brook University Medical School, Stony Brook University, BST 8-140, Stony Brook, NY 11794-8651, USA;

    Department of Geosciences, Earth and Space Sciences Building, Stony Brook University, Stony Brook, NY 11784-2100, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Pyrite; Iron Coal workers' pneumoconiosis; Inflammatory stress response;

    机译：黄铁矿;铁煤工人尘肺;炎症应激反应;

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