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首页> 外文期刊>Child Neuropsychology >Methylphenidate, Interstimulus Interval, and Reaction Time Performance of Children with Attention Deficit/Hyperactivity Disorder: A Pilot Study
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Methylphenidate, Interstimulus Interval, and Reaction Time Performance of Children with Attention Deficit/Hyperactivity Disorder: A Pilot Study

机译：注意缺陷/多动障碍儿童的哌醋甲酯，刺激间隔和反应时间表现：一项初步研究

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摘要

Thirteen children with attention deficit/hyperactivity disorder (ADHD: DSM-IV-TR) participated in the pilot study. They carried out a Go/No-Go test with a short (2 seconds) and long (6 seconds) interstimulus interval (ISI) when on placebo and a therapeutic dose of methylphenidate (MPH). For the long-ISI placebo condition the responses were slow and inaccurate. This pattern of response may be due to underactivation of the readiness-to-respond state that is not fully controlled by effort allocation. Speed of response and accuracy were enhanced during the short-ISI placebo condition and the long-ISI MPH condition. However, the combined effect (short ISI and MPH) resulted in a fast but inaccurate response style. This pattern of response may be due to overactivation of the readiness-to-respond state. The data of the pilot study support the stimulus shift hypothesis: MPH administration result in deterioration on tests on which children had previously done well (short ISI plus placebo versus short ISI plus MPH). In addition, the data support the idea that ADHD is associated with poor state regulation rather than motivational (delay aversion) theories or temporal-processing/time-estimation theories of ADHD. The pilot study defined empirically an issue for further study with the larger controlled sample.
机译：十三名注意力不足/多动障碍儿童（ADHD：DSM-IV-TR）参加了这项初步研究。他们使用安慰剂和治疗剂量的哌醋甲酯（MPH）进行了短暂（2秒）和较长（6秒）刺激间隔（ISI）的Go / No-Go测试。对于长时间的ISI安慰剂，反应缓慢且不准确。这种响应模式可能是由于未完全由工作量分配控制的准备就绪状态的激活不足引起的。在短期ISI安慰剂和长期ISI MPH条件下，反应速度和准确性均得到提高。但是，综合效果（较短的ISI和MPH）导致快速但不准确的响应方式。这种响应模式可能是由于准备就绪状态的过度激活所致。初步研究的数据支持刺激转移假说：MPH给药导致儿童先前表现良好的测试恶化（短ISI加安慰剂与短ISI加MPH）。此外，数据支持多动症与不良状态调节相关联的想法，而不是多动症的动机（延迟厌恶）理论或时间处理/时间估计理论。初步研究从经验上定义了一个问题，需要对更大的受控样本进行进一步研究。

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  • 来源
    《Child Neuropsychology》 |2009年第6期|554-566|共13页
  • 作者

    J. J. van der Meere; R. S. Shalev; N. Borger; J. R. Wiersema;

  • 作者单位

    Department of Clinical and Developmental Psychology, Groningen, The Netherlands;

    Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel;

    Department of Clinical and Developmental Psychology, Groningen, The Netherlands;

    Experimental-Clinical and Health Psychology, Ghent University, Belgium;

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  • 正文语种 eng
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  • 关键词

    ADHD; MPH; ISI; Reaction time; State regulation;

    机译：多动症;MPH;ISI;反应时间;国家法规;

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