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首页> 外文期刊>The Chinese-German Journal of Clinical Oncology >The expression and significance of the multidrug resistance-related proteins P-gp, MRP and LRP in human non-small cell lung cancer tissues
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The expression and significance of the multidrug resistance-related proteins P-gp, MRP and LRP in human non-small cell lung cancer tissues

机译：多药耐药相关蛋白P-gp，MRP和LRP在人非小细胞肺癌组织中的表达及意义

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摘要

Objective: To explore the expression and significance of the multidrug resistance-related proteins P-glycopro tein (P-gp), multidrug resistance-related protein (MRP), lung resistance protein (LRP) in human non-small cell lung cancer (NSCLC) tissues and paratumor tissues. Methods: Immunohistochemistry (IHC) was used to examine the expression level of proteins P-gp, MRP and LRP in 43 samples of NSCLC and 15 samples of paratumor tissues. Results: The expression rates of P-gp, MRP and LRP in 43 tumor tissues were 74.42% (32/43), 67.44% (29/43) and 88.37% (38/43), respectively, while in 15 paratumor tissues were 13.33% (2/15), 20.00% (3/15) and 6.67% (1/15), respectively. There was significant difference in the expression of proteins (P-gp, MRP and LRP) between lung cancer tissues and paratumor tissues (P < 0.05). The expression of proteins P-gp, LRP in lung adenocarcinoma were higher than that in other pathological carcinomas (P < 0.05). The expression of protein MRP was not related to pathological type, clinical stage and classification of histodifferentiation (P > 0.05). Conclusion: Multidrug resistance is more common in NSCLC. The proteins of P-gp, MRP and LRP participated in the formation of multidrug resistance in lung cancer. Detection of multidrug resistance-related proteins in lung cancer tissues may be useful to choice drugs.
机译：目的：探讨多药耐药相关蛋白P-糖蛋白（P-gp），多药耐药相关蛋白（MRP），肺耐药蛋白（LRP）在人非小细胞肺癌（NSCLC）中的表达及意义）组织和癌旁组织。方法：采用免疫组织化学方法（IHC）检测43例NSCLC和15例癌旁组织中P-gp，MRP和LRP蛋白的表达水平。结果：P-gp，MRP和LRP在43个肿瘤组织中的表达率分别为74.42％（32/43），67.44％（29/43）和88.37％（38/43），而在15个癌旁组织中13.33％（2/15），20.00％（3/15）和6.67％（1/15）。肺癌组织和癌旁组织之间的蛋白质（P-gp，MRP和LRP）表达存在显着差异（P <0.05）。肺腺癌中P-gp，LRP蛋白的表达高于其他病理性癌（P <0.05）。蛋白MRP的表达与病理类型，临床分期和组织分化分类无关（P> 0.05）。结论：多药耐药性在NSCLC中更为常见。 P-gp，MRP和LRP的蛋白质参与了肺癌多药耐药性的形成。在肺癌组织中检测与多药耐药相关的蛋白质可能对选择药物有用。

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