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首页> 外文期刊>The Chinese-German Journal of Clinical Oncology >The Relationship between the Expression of p27~(Kip1), p53 and the Infiltration, Metastasis and Prognosis in Gastric Carcinoma
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The Relationship between the Expression of p27~(Kip1), p53 and the Infiltration, Metastasis and Prognosis in Gastric Carcinoma

机译：p27〜（Kip1），p53的表达与胃癌浸润转移及预后的关系

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摘要

Objective: To study the relationship between the expression of p27~(Kip1) and p53, and the infiltration, metastasis and prognosis in gastric carcinoma. Methods: The expression of p27~(Kip1) and p53 at protein level was determined by immunohistochemical assay (two-step method) in 100 cases of gastric carcinoma. Results: Of the 100 cases, the positive rate of p27~(Kip1) and p53 expressions were 44% and 49%, respectively. In the group of gastric carcinomas with deep infiltration (infiltration group), lymph nodes metastasis group (metastasis group) and death-within-5-years group (death group), the expression of p27~(Kip1) was statistically lower (P < 0.05). In the metastasis group and death group, the expression of p53 was significantly higher (P < 0.05). The results of the monovariate analysis revealed that the 5-year survival rate of the high p27~(Kip1) expression group was 70.59%, which is higher than those of the low p27~(Kip1) expression group (54.55%) and the negative experession group (26%). The 5-year survival rate of the high p53 expression group was 19.23%, which was lower than those of the p53 low expression group (43.75%) and the negative group (53.19%). Cox multivariate analysis showed that p27~(Kip1), like p53, was an independent prognostic index. But p27~(Kip1) protein expression was a stronger independent survival predictor (RR = 3.06) than p53 expression (RR = 2.33). Conclusion: The low expression of p27~(Kip1) and the high expression of p53 reflected the more frequent invasion and metastasis, which resulted in the reduced survival of patients. As an independent markers of the gastric carcinoma, the expression of p27~(Kip1) is more useful than that of p53 in the prognosis prediction of gastric carcinoma.
机译：目的：探讨p27〜（Kip1）和p53的表达与胃癌浸润，转移及预后的关系。方法：采用免疫组织化学法（两步法）检测100例胃癌组织中p27〜（Kip1）和p53蛋白的表达。结果：100例患者中，p27〜（Kip1）和p53表达的阳性率分别为44％和49％。在胃癌深浸润组（浸润组），淋巴结转移组（转移组）和5年以内死亡组（死亡组）中，p27〜（Kip1）的表达在统计学上较低（P < 0.05）。在转移组和死亡组中，p53的表达显着升高（P <0.05）。单因素分析结果表明，高p27〜（Kip1）表达组的5年生存率为70.59％，高于低p27〜（Kip1）表达组的5年生存率，为负。专业组（26％）。 p53高表达组的5年生存率是19.23％，低于p53低表达组（43.75％）和阴性组（53.19％）。 Cox多变量分析显示p27〜（Kip1）与p53一样，是独立的预后指标。但是，p27〜（Kip1）蛋白表达比p53表达（RR = 2.33）具有更强的独立生存预测因子（RR = 3.06）。结论：p27〜（Kip1）的低表达和p53的高表达反映了更频繁的侵袭和转移，导致患者生存率降低。作为胃癌的独立标志物，p27〜（Kip1）的表达在预测胃癌的预后方面比p53更有用。

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