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首页> 外文期刊>The Chinese-German Journal of Clinical Oncology >Detection of Unknown Primary Tumors Using Whole Body FDG PET
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Detection of Unknown Primary Tumors Using Whole Body FDG PET

机译：使用全身FDG PET检测未知的原发性肿瘤

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摘要

Objective: To assess the usefulness of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in locating occult primary lesions. Methods: 50 patients with varying heterogeneous metastases of unknown primary origin were referred for FDG PET. The locations of the known metastatic tumor manifestations were distributed as follows: cervical lymph nodes metastases (n=18), skeletal metastases (n=15), cerebral metastases (n=12), others (n=5). All patients underwent whole body ~(18)F-FDG PET imaging. The images were interpreted by visual inspection and semi-quantitative analysis (standardized uptake value, SUV). The patients had undergone conventional imaging within 2 weeks of FDG PET. Surgical, clinical and histopathologic findings were used to assess the performance of FDG PET. Results: FDG PET was able to detect the location of the primary tumor in 32/50 patients (64%). The primary tumors were proved by histopathologic results, and located in the lungs (n=17), the nasopharynx (n=9), the breast (n=2), the ovary (n=1), the colon(n=1), the prostate(n=1),the thyroid (n=1). FDG PET were proved false positive in 2 patients (4%), and the suspicious primary tumors were in uterus and colon respectively. During the clinical follow-up of 2 to 26 months, the primary tumor was found in only 2 patients ( prostate cancer, gastric cancer). Conclusion: PET imaging allows identification of the primary site and metastatic lesions (including bone and soft tissue metastases) at a single examination. Whole body ~(18)F-FDG PET allows effective localization of the unknown primary site of origin and can contribute substantially to patient care.
机译：目的：评估2- [氟-18]氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）在隐匿性原发灶定位中的实用性。方法：将50例原发性未知的异种转移病灶转移至FDG PET。已知转移性肿瘤表现的位置分布如下：颈部淋巴结转移（n = 18），骨骼转移（n = 15），脑转移（n = 12），其他（n = 5）。所有患者均进行了全身〜（18）F-FDG PET显像。通过目测和半定量分析（标准摄取值，SUV）解释图像。患者在FDG PET的2周内接受了常规成像。手术，临床和组织病理学检查结果用于评估FDG PET的性能。结果：FDG PET能够检测32/50患者（64％）的原发肿瘤位置。通过组织病理学结果证实原发性肿瘤位于肺（n = 17），鼻咽（n = 9），乳房（n = 2），卵巢（n = 1），结肠（n = 1） ），前列腺（n = 1），甲状腺（n = 1）。 FDG PET在2例患者中被证实为假阳性（4％），可疑的原发肿瘤分别在子宫和结肠。在2到26个月的临床随访期间，仅2例患者发现了原发肿瘤（前列腺癌，胃癌）。结论：PET成像可在一次检查中识别出主要部位和转移灶（包括骨和软组织转移灶）。全身〜（18）F-FDG PET可以有效定位未知的主要起源部位，并且可以为患者的护理做出重要贡献。

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