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首页> 外文期刊>Chinese Journal of Chemical Engineering >Micronization of Griseofulvin by Ress in Supercritical CO_2 with Cosolvent Acetone
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Micronization of Griseofulvin by Ress in Supercritical CO_2 with Cosolvent Acetone

机译：树脂与助溶剂丙酮在超临界CO_2中使灰黄霉素微粉化

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摘要

Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducing particle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF. Carbon dioxide with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in supercritical CO_2 with cosolvent acetone was measured using a dynamic apparatus at pressures between 12 and 32 MPa, temperatures at 313, 323 and 333 K and cosolvent concentration at 1.5, 3.0, 4.5 and 6.0% (by mole). The effect of pre-expansion pressure, extraction temperature, spraying distance, nozzle size and concentration of cosolvent on the precipitated particles was investigated. The results show that the mean particle size of griseofulvin precipitated by RESS was less than 1.2μm. An increase in pre-expansion pressure, extraction temperature, spraying distance and concentration of cosolvent resulted in a decrease in particle size under the operating condition studied. With the decrease of nozzle diameter the particle size reduces. The crystallinity and melting point of the original material and the processed particle by RESS were tested by X-ray diffraction (XRD) and differential scanning calorimetry (DSC). No evident modification in the crystal habit was found under the experimental conditions tested. The morphology of particles precipitated was analyzed by scanning electron microscopy (SEM).
机译：灰黄霉素（GF）是一种抗真菌药物，其药物活性可以通过减小粒径来提高。在这项研究中，超临界溶液（RESS）的快速膨胀被用于微粉化GF。选择二氧化碳和助溶剂丙酮作为超临界混合溶剂。使用动态装置在压力为12至32 MPa，温度为313、323和333 K，助溶剂浓度为1.5％，3.0、4.5和6.0％（摩尔）的条件下，使用动态仪器测量GF在超临界CO_2和助溶剂丙酮中的溶解度。研究了预膨胀压力，萃取温度，喷雾距离，喷嘴尺寸和助溶剂浓度对沉淀颗粒的影响。结果表明，RESS沉淀出的灰黄霉素的平均粒径小于1.2μm。在研究的工作条件下，预膨胀压力，萃取温度，喷涂距离和助溶剂浓度的增加导致粒径减小。随着喷嘴直径的减小，粒径减小。通过X射线衍射（XRD）和差示扫描量热法（DSC）测试原始材料和通过RESS处理的颗粒的结晶度和熔点。在测试的实验条件下，没有发现晶体习性的明显改变。通过扫描电子显微镜（SEM）分析沉淀的颗粒的形态。

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