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首页> 外文期刊>Chinese Jouranl of Integrative Medicine >Study on Graded Therapy of Hemophilic Arthritis by Integrative Traditional Chinese and Western Medicine
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Study on Graded Therapy of Hemophilic Arthritis by Integrative Traditional Chinese and Western Medicine

机译：中西医结合对血友病关节炎的分级治疗研究

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Objective: To study the effect and safety of graded therapy featuring integrative traditional Chinese and Western medicine for the treatment of hemophilic arthritis. Methods: Forty patients with hemophilic arthritis were hospitalized randomly, with their blood coagulation factor activity determined by one-stage method and their arthritis classified into 4 stages. The treatment was applied according to the stage of arthritis and finding of intra-articular cavity puncture. For stage Ⅰ, based on the principle of RICE (rest, ice, compression and elevation), 1.8 g of Xuefuda (血府 达) was medicated orally once per day, intravenous dripping of 250 mL of hemostasis mixture twice a day and 1.2 g of clindamycin per day were also given for hemostasis and anti-inflammation. For stage Ⅱ-Ⅲ, Kangyanling (抗炎灵) was additionally administered via intra-articular cavity injection twice a week, 2 mL every time, for 5-6 times in total. For stage Ⅳ, the drug for intra-articular cavity injection was replaced with 25 mg of sodium hyaluronate and the frequency of injection reduced to every two weeks, for 5-6 times in total. Coagulation factors Ⅲ and Ⅳ as well as blood plasma were not given in the whole treatment course. Short-term therapeutic effects and adverse reaction in patients were evaluated, and the long-term effects were followed-up after patients left the hospital with 6-month consolidation therapy by Xuefuda. Results: After a 3-week treatment, 33 patients (82.5%) were completely remitted; 5 (12.5%) were partially remitted and 2 (5.0%) un-remitted, setting the short-term effective rate at 95.0% (38 cases). The 6-month follow-up showed that except for a relapse in 2 and 4 patients of stage Ⅲ and Ⅳ respectively, long-term remission displayed in all the other 34 patients, with the remission sustaining rate being 85.0%. No complication such as an infection, bleeding or aggravating pain occurred in the 215 times intra-articular puncturing conducted in the 40 patients. Normal figures were shown in liver and kidney function, electrolytes, ECG, blood glucose and routine test of blood and urine throughout the course. Conclusion: The graded treatment of integrative medicine for hemophilia with non-blood preparation has a favorable effect and is safe or without any adverse reaction, which opens a high efficacy and new safe path and thinking for the treatment of and deformity prevention in the hemophilic patients.
机译：目的：探讨中西医结合治疗分级治疗血友病性关节炎的疗效和安全性。方法：将40例血友病性关节炎患者随机入院，采用一阶段法测定其凝血因子活性，将关节炎分为四个阶段。根据关节炎的阶段和关节腔内穿刺的发现进行治疗。对于Ⅰ期，根据RICE（休息，冰，压迫和抬高）的原理，每天口服一次1.8 g的血府达血药达，每天两次静脉滴注250 mL止血混合物和1.2 g每天还要服用克林霉素，以止血和消炎。对于Ⅱ-Ⅲ期，每周两次通过关节腔内注射抗炎灵（抗炎灵），每次2 mL，共5-6次。对于Ⅳ期，将关节腔内注射药物替换为25 mg透明质酸钠，注射频率减少至每两周一次，共5至6次。在整个治疗过程中均未给予凝血因子Ⅲ和Ⅳ以及血浆。对患者的短期治疗效果和不良反应进行了评估，并对患者接受血复达的6个月巩固治疗离开医院后的长期效果进行了随访。结果：经过3周的治疗，33例患者（82.5％）完全缓解；部分汇入的有5（12.5％），未汇入的有2（5.0％），短期有效率为95.0％（38例）。六个月的随访表明，除了分别复发的Ⅲ期和Ⅳ期的2例和4例中，其余34例均表现出长期缓解，缓解维持率为85.0％。 40例患者进行了215次关节腔内穿刺，未发生感染，出血或加重疼痛等并发症。在整个疗程中，肝脏和肾脏功能，电解质，心电图，血糖以及血液和尿液的常规检查均显示正常值。结论：非血栓制剂对血友病中西医结合治疗效果良好，安全，无不良反应，为血友病患者的治疗和预防畸形开辟了高效，新的安全途径和思路。 。

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