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首页> 外文期刊>Chinese Journal of Integrated Traditional and Western Medicine >Intratubal Methotrexate Injection Combined with Chinese Herbal Medicine for Tubal Pregnancy and Following Pregnancy Prognosis
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Intratubal Methotrexate Injection Combined with Chinese Herbal Medicine for Tubal Pregnancy and Following Pregnancy Prognosis

机译：输卵管内注射甲氨蝶呤联合中草药治疗输卵管妊娠及妊娠预后

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Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection(IMI) alone and combination of IMI with Chinese herbal medicine. Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chor ionic gonadotro-pin β (β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse. Results: The treatment of all the 35 women was successful. The recovery duration of serum β-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0+-7.8 days, 1.2+-0.7 months and 10.7+-2. 9 days respectively, which were significantly different from those in the control group (24. 4 +-8.1 days, 3. 6+-1.7 months and 19.1+-3.2 days respectively(P<0. 05, P<0. 01 and P<0. 05 respectively) , but the existent time of fetal cardiac beat in the two groups (8.8+-1.9 days vs 9.0+-1.3 days) was not significantly different (P>0. 05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43. 8% respectively, that in the treatment group was less significant (P<0.05). The relapse rate of EP in the treatment group was insignificantly different from that in the control group (5.3% vs 18.8%, P>0.05). Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain e-qual efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.
机译：目的：比较单纯输卵管内甲氨蝶呤注射液（IMI）和中药联合IMI治疗输卵管妊娠及其第二次妊娠的效果。方法：将35例TP未破裂的患者随机分为两组，治疗组19例采用IMI联合异位妊娠汤2号（中药EP2）治疗。 ，而对照组中的其他16名患者，仅IMI被用作对照。测量治疗前后的人绒毛膜促性腺激素β（β-HCG）血清浓度，妊娠囊大小，胎儿心跳和腹膜液的存在时间。结束治疗后6个月进行子宫输卵管造影，以证实输卵管阻塞的存在和复发情况。结果：所有35名妇女的治疗均成功。治疗组血清β-HCG恢复时间，TP囊消失时间和腹膜液存在时间分别为20.0 + -7.8天，1.2 + -0.7个月和10.7 + -2。分别为9天，与对照组相比有显着差异（分别为24. 4 + -8.1天，3。6 + -1.7个月和19.1 + -3.2天（P <0。05，P <0.01。 P <0。05），但两组胎心搏动的存在时间（8.8 + -1.9天和9.0 + -1.3天）无显着差异（P> 0。05）。两组梗阻发生率分别为10.5％和43.8％，治疗组显着性较低（P <0.05），治疗组EP的复发率与对照组无明显差异（5.3）。 ％vs. 18.8％，P> 0.05）。结论：两种疗法（单独使用IMI和IMI与EP2联合使用）在治愈TP方面具有相同的疗效，与单独使用IMI相比，联合疗法似乎具有加速TP的作用。孕囊和腹膜液的吸收，改善输卵管通畅，改善妊娠状况，有利于即食提高再次妊娠率和减少异位妊娠的再次发生，以及增强IMI杀灭滋养细胞的作用。但是，没有足够的证据显示EP2在杀死胚胎方面的功效。

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