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Scanning for signatures of geographically restricted selection based on population genomics analysis

机译：根据种群基因组学分析扫描受地理限制的选择的签名

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Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus F_(ST) analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of F_(ST), we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection.
机译：自然选择作为人类进化的驱动力，直接影响人口分化。但是，尚不清楚自然选择在多大程度上引起了遗传分化。为了探讨这个问题，我们使用了国际HapMap项目的单核苷酸多态性（SNP）数据进行了全基因组扫描。单基因座F_（ST）分析用于评估常染色体群体中的频率差异。基于F_（ST）的经验分布，我们确定了12669个与种群分化相关的SNP和1853个受地理限制的自然选择的候选基因。基因个体发育的进一步解释揭示了候选基因的丰富化后的生物过程的121个类别。我们的结果表明，自然选择可能在人口分化中起重要作用。此外，我们的分析为我们对种群分化和自然选择的理解提供了新的线索和研究方法。

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