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Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China Sea

机译:混合发酵技术对南海地区两种红树林内生真菌应用Marinamide及其新型甲酯

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摘要

A novel 1-isoquinolone analog designated as marinamide (A) and its methyl ester (B), were produced by the application of mixed fermentation technique to two mangrove endophytic fungi (strains Nos. 1924 and 3893) from the South China Sea. Their structures were elucidated by comprehensive spectra methods (mainly by 2D NMR) as 4-(2-pyrrolyl)-1-isoquinolone-3-carboxylic acid (A) and methyl 4-(2-pyrrolyl)-1-isoquinolone-3-carboxylate (B), respectively. Compounds A and B were not obtained when either strain was cultured individually under the same conditions. The results showed that the application of mixed fermentation technique maybe represents a potentially important approach to discover novel metabolites.
机译:通过将混合发酵技术应用于南海的两种红树林内生真菌(菌株No. 1924和3893),生产了一种新型的1-异喹诺酮类似物,称为marinamide(A)及其甲酯(B)。通过全面的光谱方法(主要通过2D NMR)阐明了它们的结构,即4-(2-吡咯基)-1-异喹诺酮-3-羧酸(A)和甲基4-(2-吡咯基)-1-异喹诺酮-3-分别为羧酸盐(B)。当在相同条件下分别培养任一菌株时,未获得化合物A和B。结果表明,混合发酵技术的应用可能是发现新型代谢物的潜在重要途径。

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