Synthesis and characterization of nanoscale magnetic drug-inorganic composites

SUN Hui; ZHANG Hui; David G. Evans

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Synthesis and characterization of nanoscale magnetic drug-inorganic composites

机译：纳米磁性药物-无机复合材料的合成与表征

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The synthesis by direct coprecipitation and characterization of captopril (Cpl) and 5-aminosalicyIie acid (5-ASA) intercalated ZnAI layered double hydroxides coated on MgFe_2O_4 magnetic core particles are reported. Powder XRD analysis shows the well-defined crystallite structure of the composites. TEM and XPS results reveal that a core-shell structure involving a drug-LDHs layer coated on MgFe_2O_4 particles is formed through Zn-O-Mg and/or Al-O-Mg linkages. VSM measurements demonstrate that the novel magnetic drug-inorganic composites possess considerable magnetization.

机译：报道了通过直接共沉淀和表征将卡托普利（Cpl）和5-氨基水杨酸（5-ASA）嵌入在MgFe_2O_4磁性核颗粒上的插层ZnAI层状双氢氧化物。粉末XRD分析表明复合材料具有良好的微晶结构。 TEM和XPS结果表明，通过Zn-O-Mg和/或Al-O-Mg键形成了包含包覆在MgFe_2O_4颗粒上的药物-LDHs层的核-壳结构。 VSM测量表明，新型磁性药物-无机复合材料具有相当大的磁化强度。

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来源
《Chinese science bulletin》 |2005年第8期|p.752-757|共6页
作者
SUN Hui; ZHANG Hui; David G. Evans;
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作者单位

Ministry of Education Key Laboratory of Science and Technology of Controllable Chemical Reactions, Beijing University of Chemical Technology, Beijing 100029, China;

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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
magnetic targeted drug; zinc aluminum layered double hydroxide; captopril; 5-aminosalicylic acid; coprecipitatioa; core-shell structure;

机译：磁性靶向药物;锌铝层状双氢氧化物;卡托普利;5-氨基水杨酸;共沉淀;核-壳结构;

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Synthesis and characterization of nanoscale magnetic drug-inorganic composites

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