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Heat shock response down-regulates IL-18 expression in the murine macrophage cell line, RAW264.7

机译：热休克反应下调小鼠巨噬细胞RAW264.7中IL-18的表达

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摘要

Heat shock response is a self-defense mechanism for protection of cells and organisms from a wide range of harmful stressors. Recent studies revealed that it is involved in the regulation of cytokines expression. IL-18 is an important cytokine in mediating immune response. We studied LPS-induced IL-18 expression in heat shock treated RAW264.7 murine macrophages. Our results show that the heat shock response significantly inhibited the expression of LPS-induced pro-inflammatory cytokine IL-18. Further research on the down-regulation mechanism shows that this inhibitory effect is correlated to the great suppression of the binding activity of AP-1, which is a transcription factor binding to the promoter of IL-18 (-1120 to -1083) and regulates the transcription of IL-18. Meanwhile, we observed that the phosphorylation of JNK, which is AP-1 upstream kinase, was greatly decreased. These results confirmed that the down-regulation effect on IL-18 production in heat shock response is related to the suppression of the JNK/AP-1 signaling pathway.
机译：热激反应是一种自我防御机制，可保护细胞和生物免受各种有害胁迫的侵害。最近的研究表明，它参与细胞因子表达的调节。 IL-18是介导免疫反应的重要细胞因子。我们研究了热休克治疗的RAW264.7小鼠巨噬细胞中LPS诱导的IL-18表达。我们的结果表明，热休克反应显着抑制LPS诱导的促炎性细胞因子IL-18的表达。对下调机制的进一步研究表明，这种抑制作用与AP-1结合活性的极大抑制有关，AP-1是与IL-18（-1120至-1083）启动子结合并调节其转录的转录因子。 IL-18的转录。同时，我们观察到AP-1上游激酶JNK的磷酸化大大降低。这些结果证实，在热休克反应中对IL-18产生的下调作用与JNK / AP-1信号传导途径的抑制有关。

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  • 来源
    《Chinese science bulletin》 |2003年第8期|p. 780-785|共6页
  • 作者

    Wang Yun; Li Changlin; Wang Xingyu; Zhang Jinsong; Zhang Zongliang;

  • 作者单位

    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学现状及发展;
  • 关键词

    heat shock response; heat shock protein; IL-18; JNK/AP-1; macrophage;

    机译：热休克反应;热休克蛋白;IL-18;JNK / AP-1;巨噬细胞;

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