Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer

FANG Jianwu; HUANG Siluo; LIU Huisheng; M. Crepin; XU Tao; LIU Jianfeng

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Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer

机译：FGF-2 / FGFR信号通路在乳腺癌中的作用及其在乳腺癌中的意义

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Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. It has been proved that FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis). However, many of the biological activities of FGF-2 have been found to depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and human breast cancer.

机译：成纤维细胞生长因子2（FGF-2）是一大类蛋白质的成员，这些蛋白质结合肝素和硫酸乙酰肝素并调节多种细胞类型的功能。已经证明FGF-2刺激新血管的生长和发育（血管生成），新血管的生长和发育促成几种疾病（即癌症，动脉粥样硬化）的发病机理。然而，已发现FGF-2的许多生物学活性取决于其受体的固有酪氨酸激酶活性和第二信使，例如促分裂原活化的蛋白激酶。这篇综述将集中在肿瘤和人类乳腺癌中FGF-2 / FGFR诱导信号通路的机制上。

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来源
《Chinese science bulletin》 |2003年第15期|p.1539-1547|共9页
作者
FANG Jianwu; HUANG Siluo; LIU Huisheng; M. Crepin; XU Tao; LIU Jianfeng;
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作者单位

Institute of Biophyscis & Biochemistry of Huazhong University of Science & Technology, Wuhan 430074, China;

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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
FGF-2; MCF-7; breast cancer; signaling pathway; tumor;

机译：FGF-2;MCF-7;乳腺癌;信号通路;肿瘤;

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1. Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling [J] . Kayoko Hosaka, Yunlong Yang, Masaki Nakamura, Cell discovery. . 2018,第1期

机译：内皮FGF-2–FGFR1–PDGF-BB和血管周围FGF-2–FGFR2–PDGFRβ信号通路在肿瘤血管重塑中的双重作用
2. MicroRNA-296 functions as a tumor suppressor in breast cancer by targeting FGFR1 and regulating the Wnt/β-catenin signaling pathway [J] . W.-M. Sun, W. Tao, J.-C. Li, European review for medical and pharmacological sciences. . 2019,第23期

机译：通过靶向FGFR1并调节WNT /β-连环蛋白信号通路，MICRRNA-296用作乳腺癌中的肿瘤抑制剂
3. Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclearn factor-kappa B signaling pathways in MCF7 breast cancer cells [J] . Zhimin He Acta Biochimica et Biophysica Sinica . 2011,第8期

机译：乳腺癌抗性蛋白的上调通过MCF7乳腺癌细胞中的PI3K / Akt和核因子-κB信号通路在HER2介导的化学抗性中起作用
4. Repositioning drugs for breast cancer based on the identification of cancer related signaling pathways [C] . Wang Yin-Ying, Zhang Xiao-Dong, Yan-Fen Dai, Chinese Control Conference . 2013

机译：基于与癌症相关的信号通路的鉴定，重新定位乳腺癌药物
5. Cancer stem cells and the Hedgehog signaling pathway in breast cancer Sk-Br-3 cells [D] . Tolani, Bhairavi (Vivi) 2007

机译：乳腺癌Sk-Br-3细胞中的癌症干细胞和Hedgehog信号通路
6. Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRβ signaling pathways in tumor vascular remodeling [O] . Kayoko Hosaka, Yunlong Yang, Masaki Nakamura, 2018

机译：内皮FGF-2–FGFR1–PDGF-BB和血管周围FGF-2–FGFR2–PDGFRβ信号通路在肿瘤血管重塑中的双重作用
7. S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells [O] . Maria Francesca Santolla, Marianna Talia, Marcello Maggiolini 2021

机译：S100A4涉及由三阴性乳腺癌（TNBC）细胞中的FGF2 / FGFR1信号通路引发的刺激效果
8. Developing Breast Cancer Program at Xavier; Genomic and Proteomic Analysis of Signaling Pathways Involved in Xenohormone and MEK5 Regulation of Breast Cancer. [R] . Wiese, T. E. 2010

机译：在泽维尔开展乳腺癌项目;参与灵媒激素和mEK5调控乳腺癌的信号通路的基因组和蛋白质组学分析。

Role of FGF-2/FGFR signaling pathway in cancer and its signification in breast cancer

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